153172-35-1

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 67319-05-5 1-(methoxymethyl)-2-(phenylthio)-1H-imidazole 
• 882-33-7 diphenyldisulfane 
• 288-32-4 1H-imidazole 
• 101226-33-9 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole 

Downstream Products

• 118004-62-9 2-Phenylsulfanyl-1-(2-trimethylsilanyl-ethoxymethyl)-5-trimethylsilanyloxy-1H-imidazole 
• 153172-36-2 (3aR,4R,6S,6aS)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-6-[2-phenylsulfanyl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole 
• 199010-63-4 2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole 
• 186292-91-1 5-Iodo-2-phenylsulfanyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole 
• 180635-94-3 5-Bromo-2-phenylsulfanyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole 
• 546113-15-9 5-{(1-hydroxy)-[1-(4-methoxyphenyl)methyl]}-2-phenylthio-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 460990-44-7 1-[2-(trimethylsilyl)ethoxymethyl]-2-phenylsulfanyl-5-ethenyl-1H-imidazole 
• 546113-17-1 5-(4-methoxybenzyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 546113-16-0 5-(4-methoxybenzyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-phenylthio-1H-imidazole 
• 216314-74-8 2-phenylthio-1-[2-(trimethylsilyl)ethoxy]methyl-1H-imidazolylboronic acid 
• 180635-95-4 1-(tert-Butyl-dimethyl-silanyl)-3-[2-phenylsulfanyl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-1H-indole 
• 1309961-38-3 2-[2-phenylsulfanyl-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]cyclopentanone 

Relevant academic research and scientific papers

A new class of C-nucleoside analogues. 1-(S)-aryl-1,4-dideoxy-1,4-imino-D-ribitols, transition state analogue inhibitors of nucleoside hydrolase

The first members of new class of N-glycohydrolase transition state analogue inhibitors, 1,4-dideoxy-1,4-imino-1-(S)-phenyl-D-ribitol, 1, and 1,4-dideoxy-1,4-imino-1-(S)-(4-imidazolyl)-D-ribitol, 2, have been synthesized. The compounds represent a new typ

Extending pummerer reaction chemistry: Studies in the palau'amine synthesis area

Exploratory oxidative cyclization studies on cyclopentanelated and cyclohexenelated oroidin derivatives utilized Pummerer chemistry to generate pentacyclic structures related to the palau'amine family of sponge metabolites. Stereochemical issues were para

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.

Synthesis of a regio-isomer of kealiiquinone, a marine benzimidazole alkaloid

Treatment of 1,3-dialkyl-2-(phenylthio)benzimidazolium salts 3 and 1,3-dialkyl-2-phenylthio-1H-imidazolium salts 7 with aq. K2CO3 gives 1,3-dialky1-1,3-dihydrobenzimidazol-2-ones 4 and 1,3-dialkyl-1,3-dihydroimidazol-2-ones 8, respectively, in 22-94% yield. A regio-isomer 17 of kealiiquinone, a marine benzimidazole alkaloid, where the 4-methoxyphenyl group at the 4-position migrates to the 9-position, is synthesized by application of the reaction. Cytotoxity of 17 and kealiiquinone against 39 human cancer cells is evaluated. They have weak activity but a unique mechanism of action.

METALATIONS OF IMIDAZOLES. (POLY)FUNCTIONALIZATION AND CONVERSIONS TO IMIDAZOLONES

N-SEM protected imidazoles can be sequentially derivatized at the 2- and then 5-positions in a 1-pot operation.Quenching with selected peroxides following initial lithiation leads directly to imidazolones.