21633-79-4

Upstream product

• 27761-57-5 2-((E)-But-2-enoyl)-malonic acid diethyl ester 
• 109572-65-8 BrMgCH(CO₂Et)2 
• 141-75-3 butyryl chloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 685-88-1 fluoromalonic acid diethyl ester 
• 3249-68-1 ethyl butyroyl acetate 
• 1443120-88-4 ethyl 2-oxo-6-phenyl-4-propyl-1,2-dihydropyridine-3-carboxylate 
• 1443120-90-8 ethyl 6-(4-methoxyphenyl)-2-oxo-4-propyl-1,2-dihydropyridine-3-carboxylate 
• 1443120-91-9 ethyl 6-(4-bromophenyl)-2-oxo-4-propyl-1,2-dihydropyridine-3-carboxylate 
• 1443120-97-5 diethyl 2-(1-oxo-1-phenylhex-3-en-3-yl)malonate 
• 1443120-99-7 diethyl 2-(1-(4-methoxyphenyl)-1-oxohex-3-en-3-yl)malonate 
• 1443121-01-4 C₁₉H₂₃BrO₅ 

Relevant academic research and scientific papers

Synthesis of β-arylacyl / β-heteroarylacyl-β-alkylidene malonates and their application in substituted pyridone synthesis

A novel approach has been developed for the synthesis of β-arylacyl/β-heteroarylacyl-β-alkylidine malonates in moderate to good yields by the reaction of Stork aryl and heteroaryl enamine with β-chloroalkylidene malonates. The reaction involves conjugate

Synthesis of novel 5-alkyl/aryl/heteroaryl substituted diethyl 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates by aziridine ring expansion of 2-[(aziridin-1-yl)-1-alkyl/aryl/heteroaryl-methylene]malonic acid diethyl esters

A novel synthetic methodology has been developed for the synthesis of diethyl 5-alkyl/aryl/heteroaryl substituted 3,4-dihydro-2H-pyrrole-4,4- dicarboxylates (also called 2-substituted pyrroline-4,5-dihydro-3,3-dicarboxylic acid diethyl esters) by iodide i

PYRAZOLO ’3,4-B! PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE TYPE 4 (PDE4) INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: formula (I) wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): formulae (x), (z), (y), (y1) R1 is C1-4alkyl, C1-3

Procedures for the Acylation of Diethyl Malonate and Ethyl Acetoacetate with Acid Chlorides Using Tertiary Amine Bases and Magnesium Chloride

In the presence of magnesium chloride and 2 equiv of triethylamine, diethyl malonate is C-acylated in excellent yields by acid chlorides.A variety of other metal chlorides were ineffective.Similarly, ethyl acetoacetate is C-acylated by acid chlorides in the presence of magnesium chloride and 2 equiv of pyridine.