216390-60-2Relevant academic research and scientific papers
Synthesis of Functionalized Benzo[b]furans via Oxidative Cyclization of o-Cinnamyl Phenols
Rehan, Mohammad,Nallagonda, Rajender,Das, Braja Gopal,Meena, Tannu,Ghorai, Prasanta
, p. 3411 - 3424 (2017/04/13)
Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and benzoquinone as an oxidant. Further, a sequential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed. The reaction showed broad substrate scope with good to excellent yields.
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT2 melatonin receptor selective ligands
Wallez, Valérie,Durieux-Poissonnier, Sophie,Chavatte, Philippe,Boutin, Jean A.,Audinot, Valérie,Nicolas, Jean-Paul,Bennejean, Caroline,Delagrange, Philippe,Renard, Pierre,Lesieur, Daniel
, p. 2788 - 2800 (2007/10/03)
A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl amide derivatives were synthesized and evaluated as melatonin receptor ligands. The affinity of each compound for the two MT1 and MT2 melato
