216393-12-3

Basic information

• Product Name: (S,S)-2-acetoxycyclooctan-1-ol
• Synonyms: (S,S)-2-acetoxycyclooctan-1-ol
• CAS NO: 216393-12-3
• Molecular Weight: 186.251
• Mol File: 216393-12-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S,S)-2-acetoxycyclooctan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S,S)-2-acetoxycyclooctan-1-ol(216393-12-3)
• EPA Substance Registry System: (S,S)-2-acetoxycyclooctan-1-ol(216393-12-3)

Safety Data

• Hazardous Substances Data: 216393-12-3(Hazardous Substances Data)

Upstream product

• 42565-22-0 trans-1,2-cyclooctanediol 
• 108-24-7 acetic anhydride 
• 286-62-4 Cyclooctene oxide 
• 64-19-7 acetic acid 

Relevant articles and documents

Alcohol cross-coupling for the kinetic resolution of diols via oxidative esterification

We present an organocatalytic C-O-bond cross-coupling strategy to kinetically resolve racemic diols with aromatic and aliphatic alcohols, yielding enantioenriched esters. This one-pot protocol utilizes an oligopeptide multicatalyst, m-CPBA as the oxidant, and N,N-diisopropylcarbodiimide as the activating agent. Racemic acyclic diols as well as trans-cycloalkane-1,2-diols were kinetically resolved, achieving high selectivities and good yields for the products and recovered diols.

Kinetic resolution of trans-cycloalkane-1,2-diols via Steglich esterification

We describe the efficient and highly enantioselective kinetic resolution of trans-cycloalkane-1,2-diols utilizing an enantioselective Steglich reaction with a variety of carboxylic acids that form the corresponding anhydrides in situ.