2164-84-3

Usage

Chemical Properties

White solid

InChI:InChI=1/C4H5N5O2/c5-3-2(9(10)11)4(6)8-1-7-3/h1H,(H4,5,6,7,8)

Upstream product

• 2434-56-2 4,6-diaminopyrimidine 
• 4316-93-2 4,6-dichloro-5-nitropyrimidine 
• 64204-23-5 4-Amino-N,N,6-trimethylpteridin-7-carbonsaeureamid-5,8-dioxid 
• 61908-15-4 4,6-diamino-5-nitrosylpyrimidine 

Downstream Products

• 118-70-7 4,5,6-triaminopyrimidine 
• 112220-31-2 (2R,3R,4R,5R)-2-((6-amino-5-nitropyrimidin-4-yl)amino)-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate 
• 183004-18-4 6-amino-5-nitro-4-[(3',5'-di-O-toluyl-β-D-2'-deoxyribofuranosyl)amino]pyrimidine 
• 651030-77-2 6-amino-5-nitro-4-(β-D-ribofuranosyl-5-t-butyldiphenylsilyloxy-1,2-dibenzoyl)pyrimidine 

Relevant academic research and scientific papers

Synthesis method of 4,5,6-triaminopyrimidine

The invention discloses a synthesis method of 4,5,6-triaminopyrimidine. The synthesis method includes the following steps that an intermediate product of 4,6-dichloro-5-nitropyrimidine is prepared by5-nitro-4,6-dihydroxypyrimidine, phosphorus oxychloride and organic alkali; ethyl alcohol is added into a product prepared by the 4,6-dichloro-5-nitropyrimidine and ammonium hydroxide to obtain a product; and the 4,5,6-triaminopyrimidine is prepared by the product, hydrazine hydrate, and raney nickel. According to the synthesis method, targeted objects can be obtained just through three steps, total yield is high, synthesis routes are short, reaction is mild, time is short, operation is easy and safe, at the same time, the 4,6-dichloro-5-nitropyrimidine is taken as a starting material, due tothe fact that the starting material has a large amount of commercial supplies, and is cheap and easy to obtain, an auxiliary material can be recycled and reused, and the cost can be significantly reduced; and due to the fact that appropriate raw material and auxiliary material are selected, the pollution of toxic substances to environments in the production process is avoided, the yield and purityof prepared pyrimidine are high, and the pyrimidine has good industrial application prospects.

Pyrazine-1,4-dioxides fused to heterocyles. 3rd comm. Synthesis and antibacterial activity of substituted pteridine-5,8-dioxides

The synthesis of substituted pteridine-5,8-dioxides via reaction of furoxanes with enolizing carbonyl compounds is described. Compounds 5 are obtained either through reaction of chloro pyrimidines 1 with sodium azide, or through diazotization of hydrazino pyrimidine 2 and subsequent thermal decomposition of 3 or through nucleophilic displacement of methoxy against amino groups in 5. The antibacterial activity of the compounds 6a and 6c is directed against some gramnegative organisms, i.e. E. coli, Klebsiella spp. and Proteus spp., with MIC values and ED50 values which do not exceed those of the corresponding pyrido[2,3-b]pyrazine-1,4-dioxides.

Pyrimidine N-Oxides. III. The Oxidation of 5-Nitrosopyrimidine-4,6-diamine

The oxidation of 5-nitrosopyrimidine-4,6-diamine by hydrogen peroxide in trifluoroacetic acid has been reexamined and the products shown to be 4,6-diamino-5-nitropyrimidin-2-ol, 5-nitropyrimidine-4,6-diamine and 5-nitropyrimidine-4,6-diamine 1,3-dioxide.