2164-84-3Relevant articles and documents
Synthesis method of 4,5,6-triaminopyrimidine
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Paragraph 0022; 0025; 0027; 0030; 0032; 0035; 0037; 0040, (2019/11/14)
The invention discloses a synthesis method of 4,5,6-triaminopyrimidine. The synthesis method includes the following steps that an intermediate product of 4,6-dichloro-5-nitropyrimidine is prepared by5-nitro-4,6-dihydroxypyrimidine, phosphorus oxychloride and organic alkali; ethyl alcohol is added into a product prepared by the 4,6-dichloro-5-nitropyrimidine and ammonium hydroxide to obtain a product; and the 4,5,6-triaminopyrimidine is prepared by the product, hydrazine hydrate, and raney nickel. According to the synthesis method, targeted objects can be obtained just through three steps, total yield is high, synthesis routes are short, reaction is mild, time is short, operation is easy and safe, at the same time, the 4,6-dichloro-5-nitropyrimidine is taken as a starting material, due tothe fact that the starting material has a large amount of commercial supplies, and is cheap and easy to obtain, an auxiliary material can be recycled and reused, and the cost can be significantly reduced; and due to the fact that appropriate raw material and auxiliary material are selected, the pollution of toxic substances to environments in the production process is avoided, the yield and purityof prepared pyrimidine are high, and the pyrimidine has good industrial application prospects.
Pyrimidine N-Oxides. III. The Oxidation of 5-Nitrosopyrimidine-4,6-diamine
Cowden, William B.,Jacobsen, Noel W.
, p. 131 - 135 (2007/10/02)
The oxidation of 5-nitrosopyrimidine-4,6-diamine by hydrogen peroxide in trifluoroacetic acid has been reexamined and the products shown to be 4,6-diamino-5-nitropyrimidin-2-ol, 5-nitropyrimidine-4,6-diamine and 5-nitropyrimidine-4,6-diamine 1,3-dioxide.