61908-15-4

Basic information

• Product Name: 4,6-Pyrimidinediamine, 5-nitroso- (9CI)
• Synonyms: 4,6-Pyrimidinediamine, 5-nitroso- (9CI);5-nitroso-pyrimidine-4,6-diamine
• CAS NO: 61908-15-4
• Molecular Formula: C₄H₅N₅O
• Molecular Weight: 139.1154
• Product Categories: PYRIMIDINE
• Mol File: 61908-15-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: >350 °C
• Boiling Point: 455.1°C at 760 mmHg
• Flash Point: 229°C
• Appearance: /
• Density: 1.89g/cm³
• Vapor Pressure: 1.8E-08mmHg at 25°C
• Refractive Index: 1.833
• PKA: 3.07±0.10(Predicted)
• CAS DataBase Reference: 4,6-Pyrimidinediamine, 5-nitroso- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Pyrimidinediamine, 5-nitroso- (9CI)(61908-15-4)
• EPA Substance Registry System: 4,6-Pyrimidinediamine, 5-nitroso- (9CI)(61908-15-4)

Safety Data

• Hazardous Substances Data: 61908-15-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5N5O/c5-3-2(9-10)4(6)8-1-7-3/h1H,(H4,5,6,7,8)

Upstream product

• 5468-67-7 4,6-diaminopyrimidine hydrochloride 
• 2434-56-2 4,6-diaminopyrimidine 

Downstream Products

• 22003-13-0 [1,2,5]oxadiazolo[3,4-d]pyrimidin-7-ylamine 
• 79378-81-7 4-amino-6-phenyl-pteridine-7-one 
• 49721-45-1 4,5,6-triaminopyrimidine sulfate 
• 2164-84-3 4,6-Diamino-5-nitropyrimidine 
• 74730-45-3 5-nitropyrimidine-4,6-diamine 1,3-dioxide 
• 3346-24-5 4,6-diamino-5-nitropyrimidin-2-ol 
• 79378-81-7 4-amino-6-phenyl-7(8H)-pteridinone 
• 118-70-7 4,5,6-triaminopyrimidine 
• 1668-45-7 4,7-Diamino-pteridin-6-carbonsaeure-amid 
• 19172-95-3 6-phenyl-pteridine-4,7-diamine 

Relevant articles and documents

Method for synthesis of adenine (by machine translation)

The invention discloses a synthetic method for adenine. Malononitrile and thiourea are employed as raw materials. The raw materials are subjected to a cyclization reaction under action of sodium alkoxide, and 4,6-diamino-2-sulfydryl pyrimidine. Then through three reaction routes, adenine is obtained. Though the method has many reaction steps, no refining or drying are needed for the product of each reaction step, the product can be used in the next reaction step, and the operation is simple. The raw materials are easily available, the prices are relatively low, the reaction conditions are mild, the operation is simple, the reaction steps are decreased, the reaction time is shortened, the overall reaction yield is high, and the synthetic method is suitable for industrial production.

Nucleosides part LXVI I[1]: Synthesis of 4-amino-7(8H) pteridinone-N8-nucleosides-structural analogs of adenosine

Various 4-amino-7(8H)pteridones (6, 12, 14, 15, 20, 22) have been glycosylated with 1-chloro-2'-deoxy-D-ribofuranose derivatives (25, 26) applying the new DBU-salt method to form the N8-2'-deoxy-D-ribofuranosides (27-36) which can be regarded as 2'-deoxyadenosine analogs. Analogously reacted the 2-N,N-dimethyl-amino-methyleneimino-7(8H)pteridones (43-48) to give preferentially the corresponding N8-ss-D-anomers (49-55). Ribosylation with 1-bromo-2,3,5-tri-O-benzoyl-a-D-ribofuranose (56) proceeded as well with 6, 12, 15, 45, and 46 to yield to N8-ss-D-ribofuranosides 57-61. Sugar deprotection led to the free N8-2'-deoxy-ss-D-ribofuranosides 37-42 and N8-ss-D-ribofurano-sides 62-65, respectively. Glycosylations via the silyl-method under Vorbruggen conditions led with 6, 12 and 15 to the same results, however, 4-amino-6-phenyl-7(8H)pteridone (14) reacted differently forming the N1-ss-D-ribofuranosides (71, 79) and the N1-2'-deoxy - and ss-D-ribofuranosides 73, 74, 77, 78. The assignments of the structures have been achieved by 1H-NMR- and UV-spectra. C,H,N-elemental analyses account for the composition.