216443-85-5Relevant academic research and scientific papers
Novel synthesis of the 2-azaanthraquinone alkaloid, scorpinone, based on two microwave-assisted pericyclic reactions
Choshi, Tominari,Kumemura, Teppei,Nobuhiro, Junko,Hibino, Satoshi
, p. 3725 - 3728 (2008)
The total synthesis of the 2-azaanthraquinone alkaloid, scorpinone (4), isolated from the mycelium of a Bispora-like tropical fungus, has been completed in nine steps. The two key steps involve a microwave-assisted thermal electrocyclic reaction for the synthesis of an 8-oxygenated isoquinoline skeleton from a 1-aza 6π-hexatriene system, and a regioselective microwave-assisted [4+2] cycloaddition for the construction of a 2-azaanthraquinone framework.
Construction of spirofused tricyclic frameworks by NHC-catalyzed intramolecular stetter reaction of a benzaldehyde tether with a cyclic exsnone
Hsu, Day-Shin,Cheng, Chiao-Yun
, p. 10832 - 10842 (2019/09/30)
Various benzaldehyde tethers with a cyclic enone were prepared from commercially available 2-hydroxybenzaldehydes via a three-step sequence involving triflate formation, Sonogashira cross-coupling, and regioselective hydrogenation. These substrates were t
CHEMICAL COMPOUNDS 637
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Page/Page column 442, (2008/12/07)
The present invention provides a compound of a formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.
Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
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, (2008/06/13)
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
