216480-96-5

Upstream product

• 1146435-74-6 C₁₃H₂₂N₂O₄S 
• 1025830-13-0 2-((S)-1-tert-Butoxycarbonylamino-ethyl)-4-hydroxy-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester 
• 70-23-5 ethyl Bromopyruvate 
• 96929-06-5 ethyl 2-<(S)-1-(N-t-butoxycarbonyl)aminoethyl>thiazole-4-carboxylate 

Downstream Products

• 251349-64-1 2-{(S)-1-[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-ethyl}-thiazole-4-carboxylic acid ethyl ester 
• 1453168-09-6 C₂₂H₃₀N₄O₅S 
• 1453168-06-3 C₅₂H₆₃N₉O₁₁S₂ 
• 1453168-12-1 C₄₅H₄₉N₉O₈S₂ 
• 1453168-13-2 C₃₇H₄₃N₉O₆S₂ 
• 1453168-14-3 C₅₈H₇₈N₁₂O₁₃S₃ 
• 1158821-83-0 (S)-N-(2-phenethyl)-2-(1-acetamidoethyl)thiazole-4-carboxamide 
• 1588428-08-3 C₂₂H₂₉N₃O₅S 
• 1588428-07-2 C₂₂H₂₉N₃O₅S 
• 1588428-00-5 C₃₇H₄₂N₈O₆S₂ 
• 1588428-17-4 C₁₇H₂₁N₃O₃S 
• 1588427-99-9 C₃₇H₄₂N₈O₆S₂ 
• 1588428-14-1 C₁₇H₂₁N₃O₃S 

Relevant academic research and scientific papers

Sanguinamide B analogs: Identification of active macrocyclic structures

We report the synthesis of three new sanguinamide B (San B) analogs. We substituted in amino acids along the San B backbone with an N-Me, glycine, or an aromatic moiety (Phe or d-Phe) generating twelve derivatives in total. Testing in HCT-116 colon cancer

Mechanistic studies of sanguinamide B derivatives: A unique inhibitor of eukaryotic ribosomes

Described are mechanistic studies of two Sanguinamide B (San B) derivatives. These compounds were identified as eukaryotic ribosomal inhibitors. Two biotinylated San B derivatives were synthesized and used to capture protein targets in a pull-down assay.

Total syntheses of bacillamide C and neobacillamide A; Revision of their absolute configurations

The enantiospecific syntheses of both enantiomers of bacillamide C and neobacillamide A are described, along with the measurement of their optical activities, leading to the revision of the proposed absolute configurations of these natural products.

Total synthesis of trans, trans- Sanguinamide B and conformational isomers

The first total synthesis of Sanguinamide B is reported, prepared via an efficient synthetic strategy. The natural product, trans,trans-Sanguinamide B (1), was generated in a thermodynamic ratio with trans,cis-Sanguinamide B (2) and cis,cis-Sanguinamide B

Synthesis and antimicrobial activity in vitro of new amino acids and peptides containing thiazole and oxazole moieties

2-(Pyrrolidinyl)thiazole-4-carboxylic acid 5d, 2-(1-aminoalkyl)thiazole- 4-carboxamides and hydrazides 8, 10 have been synthesized using alanine, valine, and proline as educts. In addition oxazole amino acids derived from leucine 20a and alanine 20b and some peptides 13, 14, 16 containing the 5- ring heterocyclic backbone modifications have been prepared. The thiazole and oxazole containing amino acids and peptides showed moderate antibacterial activity in vitro against various Gram-positive (Staphylococcus aureus, Bacillus cereus, etc.) and Gram-negative (Escherichia coli, Proteus vulgaris, etc.) bacteria, fungi (Candida albicans), and yeast (Saccharomyces cerevisae, etc.).

Synthesis of Dolastatin I, a cytotoxic cyclic hexapeptide from the sea hare Dolabella auricularia

Dolastatin I, a cytotoxic cyclic hexapeptide isolated from the Japanese sea hare Dolabella auricularia, was enantioselectively synthesized, which confirmed its stereostructure.