216482-60-9

Basic information

• Product Name: 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾
• CAS NO: 216482-60-9
• Molecular Weight: 275.361
• Mol File: 216482-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾(216482-60-9)
• EPA Substance Registry System: 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾(216482-60-9)

Safety Data

• Hazardous Substances Data: 216482-60-9(Hazardous Substances Data)

Upstream product

• 33143-80-5 3-(p-cyanophenoxy)-1-propyne 

Downstream Products

• 216482-59-6 1-(4-[imino(ethoxy)methyl]phenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾ hydrochloride 

Relevant articles and documents

Synthesis of an o-Carboranyl Derivative of 4-[5-(4-Methyl-1-piperazinyl)-2,5′-bi-1H-benzimidazol-2′-yl]phenol

Synthesis of an o-carboranyl derivative of 4-[5-(4-methyl-l-piperazinyl)-2,5′-bi-1H-benzimidazol-2′-yl]phenol (1), a candidate for application in boron neutron capture therapy for cancer treatment, is described. Decaborane was introduced into 3-(p-cyanophenoxy)-1-propyne (11) to form l-(4-cyanophenoxymethyl)-1,2-dicarba-dayododecaborane(12) (12), which was transformed into the corresponding imidate 10 in order to be coupled with 4-cyano-ophenylenediamine (13) to give 1-[4-(5′-cyano-1H-benzimidazol-2′-yl)phenoxymethyl]-1,2-dicarba- c7o5ododecaborane(12) (14). The latter was reacted to the related imidate salt 15 and condensed with 5-(4-methyl-1-piperazinyl)-o-phenylenediamine (6) to the title compound 1-{4-[5-(4-methyl-l-piperazinyl)-2,5′-bi-1H-benzimidazol-2′-yl] phenoxymethyl}-1,2-dicarba-closo-dodecaborane(12) (2).