33143-80-5

Upstream product

• 767-00-0 4-cyanophenol 
• 2450-71-7 Propargylamine 
• 107-19-7 propargyl alcohol 
• 619-72-7 4-nitrobenzonitrile 
• 1079882-90-8 1-(azidomethyl)-4-(prop-2-yn-1-yloxy)benzene 
• 34905-02-7 [4-(prop-2-yn-1-yloxy)phenyl]methanol 
• 5651-86-5 4-(prop-2-ynyloxy)benzaldehyde 
• 106-96-7 propargyl bromide 

Downstream Products

• 943026-55-9 (4-(prop-2-yn-1-yloxy)phenyl)methanamine 
• 1613586-56-3 4-(prop-2-yn-1-yloxy)benzylphthalimide 
• 1613586-57-4 4-(prop-2-yn-1-yloxy)benzylnaphthaleimide 
• 1613586-58-5 2-((4-(prop-2-yn-1-yloxy)benzyl)carbamoyl)benzoic acid 
• 1641528-50-8 C₃₉H₃₂N₄O₅ 
• 1417919-51-7 (hexacarbonyldicobalt)propargyl para-cyanophenyl ether 
• 1383455-03-5 3-(4-cyanophenoxy)-1-phenylprop-1-yne 
• 1383455-15-9 3-(N-benzylisoindolin-1-onyl)-6-cyano-4-phenyl-2H-chromene 
• 1393750-83-8 C₂₈H₂₉F₂N₅O₁₀ 
• 1352840-47-1 C₄₀H₄₇N₉O₂ 
• 1352840-39-1 C₂₀H₁₉NO₂ 
• 1334667-59-2 1-(4-cyanophenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-34-3 1-(4,4'-dicyanodiphenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 16238-12-3 2-methylbenzofuran-5-carbonitrile 

Relevant academic research and scientific papers

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

Light-emitting diode light–enabled denitrative etherification of 4-nitrobenzonitrile under catalyst-free conditions at room temperature

In this study, we have developed a catalyst-free procedure for denitrative etherification of electron-deficient nitroarenes. In this method, the reaction failed in the dark but was enabled by white light-emitting diode light (6 W) in the presence of NaOH/dimethylformamide at room temperature with short reaction times. Interestingly, the reaction in the dark is completed almost immediately once a small quantity of water is added to the reaction mixture. Ultraviolet irradiation (λ = 254 nm) was not effective for this reaction to proceed.

Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis

A total of forty-three compounds were synthesized, including thirty-two new ones. Among those compounds, seventeen were selected and tested on human tumor cell lines: PC-3 (prostate adenocarcinoma), HCT-116 (colorectal tumor), NCIH-460 (lung carcinoma), S

Multitasking with Chemical Fuel: Dissipative Formation of a Pseudorotaxane Rotor from Five Distinct Components

A 3-fold completive self-sorted library of dynamic motifs was integrated into the design of the pseudorotaxane-based rotor [Zn(2·H+)(3)(4)]2+ operating at k298 = 15.4 kHz. The rotational motion in the five-component device is based on association/dissocia

Amidine-and amidoxime-substituted heterocycles: Synthesis, antiproliferative evaluations and dna binding

The novel 1,2,3-triazolyl-appended N-and O-heterocycles containing amidine 4–11 and amidoxime 12–22 moiety were prepared and evaluated for their antiproliferative activities in vitro. Among the series of amidine-substituted heterocycles, aromatic diamidin

Uniform copper nanoparticles as an inexpensive and efficient catalyst for synthesis of novel β-carbonyl-1, 2, 3-triazoles in water medium

Copper nanoparticles as an efficient, inexpensive catalyst were prepared via ball milling for synthesis of β-carbonyl 1, 2, 3-triazoles from azido alcohol by click reaction in water. An extensive range of raw materials such as sodium azide, phenacyl bromi

1,2,3-Triazole-based kojic acid analogs as potent tyrosinase inhibitors: Design, synthesis and biological evaluation

A series of kojic acid-derived compounds 6a-p bearing aryloxymethyl-1H-1,2,3-triazol-1-yl moiety were designed by modifying primary alcoholic group of kojic acid as tyrosinase inhibitors. The target compounds 6a-p were synthesized via click reaction. All

Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities

Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was deve

Coumarin-1,2,3-triazole hybrid derivatives: Green synthesis and DFT calculations

A series of new 1,2,3-triazole-coumarin hybrid system are synthesized from the click reaction between 3-azido coumarin and different aromatic terminal alkyne derivatives in a green manner. All compounds are characterized by IR, NMR and UV–VIS spectroscopy

Interaction of carborane-appended trimer with bovine serum albumin: A spectroscopic investigation

The interaction of symmetrical triazine-cored carborane-appended trimer 5 with bovine serum albumin has been investigated using different spectroscopic methods. The intrinsic fluorescence of BSA was quenched by the carborane trimer 5 through the dynamic q