216484-96-7

Basic information

• Product Name: (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester
• CAS NO: 216484-96-7
• Molecular Weight: 706.028
• Mol File: 216484-96-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester(216484-96-7)
• EPA Substance Registry System: (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester(216484-96-7)

Safety Data

• Hazardous Substances Data: 216484-96-7(Hazardous Substances Data)

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 52759-80-5 methyl 3α-7α-ditrimethylsilyloxy-5β-chol-6-en-24-oate 
• 474-25-9 chenodeoxycholic acid 
• 3057-04-3 chenodeoxycholic acid methyl ester 

Relevant articles and documents

Ergosteroids III. Syntheses and biological activity of seco-steroids related to dehydroepiandrosterone

The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats' livers. Only one, 3β-acetoxy-17a-oxa-androst- 5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β- hydroxy-17a-oxa-androsta-5,15-diene- 7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β- Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D- ring seco compounds enhanced the formation of both enzymes. Twelve other D- ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active.