52759-80-5

Basic information

• Product Name: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester
• Synonyms: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester
• CAS NO: 52759-80-5
• Molecular Formula: C₃₁H₅₈O₄Si₂
• Molecular Weight: 550.96082
• Mol File: 52759-80-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(52759-80-5)
• EPA Substance Registry System: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(52759-80-5)

Safety Data

• Hazardous Substances Data: 52759-80-5(Hazardous Substances Data)

Upstream product

• 474-25-9 chenodeoxycholic acid 
• 75-77-4 chloro-trimethyl-silane 
• 10538-59-7 7-ketolithocholic methyl ester 
• 4651-67-6 7-Ketolithocholic acid 
• 3057-04-3 chenodeoxycholic acid methyl ester 

Downstream Products

• 915038-24-3 (E/Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid 
• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 
• 216484-96-7 (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 3α,7α-DIHYDROXY6α-ETHYL-5β-CHOLAN-24-OIC ACID

The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid which are useful in the preparation of pure 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid.

Process for Preparation of Sulfonyl Carbamate Bile Acid Derivatives

The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II): or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGRS modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use. The present invention relates to a process for the preparation of the compounds of Formula (III), Formula (IV), Formula (V), and Formula (VI), The present invention also relates to a process for the preparation of compounds (VII), (VIII) and (IX),

Ergosteroids III. Syntheses and biological activity of seco-steroids related to dehydroepiandrosterone

The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats' livers. Only one, 3β-acetoxy-17a-oxa-androst- 5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β- hydroxy-17a-oxa-androsta-5,15-diene- 7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β- Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D- ring seco compounds enhanced the formation of both enzymes. Twelve other D- ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active.