52759-80-5

Basic information

• Product Name: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester
• Synonyms: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester
• CAS NO: 52759-80-5
• Molecular Formula: C₃₁H₅₈O₄Si₂
• Molecular Weight: 550.96082
• Mol File: 52759-80-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(52759-80-5)
• EPA Substance Registry System: 3α,7α-Bis(trimethylsilyloxy)-5β-cholan-24-oic acid methyl ester(52759-80-5)

Safety Data

• Hazardous Substances Data: 52759-80-5(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 10538-59-7 7-ketolithocholic methyl ester 
• 4651-67-6 7-Ketolithocholic acid 
• 474-25-9 chenodeoxycholic acid 
• 3057-04-3 chenodeoxycholic acid methyl ester 

Downstream Products

• 915038-24-3 (E/Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid 
• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 
• 216484-96-7 (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3,7-bis-trimethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-phenylselanyl-pentanoic acid methyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 3α,7α-DIHYDROXY6α-ETHYL-5β-CHOLAN-24-OIC ACID

The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid which are useful in the preparation of pure 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid.

Ergosteroids III. Syntheses and biological activity of seco-steroids related to dehydroepiandrosterone

The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats' livers. Only one, 3β-acetoxy-17a-oxa-androst- 5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β- hydroxy-17a-oxa-androsta-5,15-diene- 7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β- Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D- ring seco compounds enhanced the formation of both enzymes. Twelve other D- ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active.