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Relevant academic research and scientific papers

Assembly of Water-soluble AIE-active Fluorescent Organic Nanoparticles for Ratiometric Detection of Hypochlorite in Living Cells

Hypochlorous acid (HOCl) plays a crucial role in many physiological processes and is widely used as bleach, deodorant and fungicide. In this work, we designed an amphiphilic hydrazone fluorescent molecule THG-1 containing hydrophilic sugar units and hydro

Photoinduced crystallization isoquinoline salt compound, preparation method and application thereof, and preparation method of nanocrystal

The invention belongs to the technical field of photoresponse materials, and discloses a photoinduced crystallization isoquinoline salt compound, a preparation method and application thereof, and a preparation method of nanocrystals, and the preparation m

Sensing array with mitochondrial targeting and aggregation-induced emission effects and application of sensing array in cell discrimination

The invention relates to a sensing array capable of distinguishing cells. The sensing array provided by the invention comprises five tetraphenyl ethylene derivatives with mitochondrial targeting and aggregation-induced emission effects. According to the tetraphenyl ethylene derivatives disclosed by the invention, a molecular probe D-A structure is adjusted by adjusting donor-acceptor groups and different cationic groups, so that different fluorescence spectrum properties are realized, and different electrostatic and hydrophobic interactions with cells are realized; the synthesis is easy; goodbiocompatibility and light stability are realized; cell mitochondria can be effectively targeted for cell imaging; different probes and different cells generate differential fluorescence response; byanalyzing different fluorescence responses, different cancer cells can be discriminated and cell types can be predicted. A new method for early cancer detection is designed and has potential application in the aspect of cancer cell clinical examination.

Tetraphenylethylene indole derivative, preparation method therefor and application of tetraphenylethylene indole derivative in cell imaging and thiol compound analysis

The invention provides a tetraphenylethylene indole derivative molecule, a preparation method therefor and an application of the tetraphenylethylene indole derivative molecule in the fields of cell imaging and detection of thiols in cells. According to the application, two indole salt structures are introduced to a tetraphenyl ethylene molecule, and the molecule is applied to the cell imaging and thiol compound analysis as a fluorescence molecule probe by using fluorescence emission characteristics of the molecule. Due to the introduction of the two indole salt structures, the interaction between the molecule probe and the surface of a mitochondrion in a cell can be enhanced, then, the selective imaging of the mitochondrion and the detection of a membrane potential of the mitochondrion are achieved, and a more-sensitive potential indicating result is obtained. The induced luminescence integrated fluorescence molecule provided by the invention has the advantages of low cell toxicity and good luminescence stability, can be applied to the analysis of thiol compounds, the mitochondrion imaging of the cells and the detection of membrane potential changes of mitochondria and shows a potential application value in the field of biomedicines.