216573-04-5

Upstream product

• 643-79-8 o-phthalic dicarboxaldehyde 
• 216572-92-8 Acetic acid 2-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-8-methoxy-1-phenylethynyl-oct-3-ynyl ester 
• 216572-83-7 4-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-10-methoxy-1-phenyl-deca-1,5-diyn-3-ol 
• 216572-79-1 (E)-3-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-acrylic acid methyl ester 
• 216572-81-5 (Z)-2-Bromo-3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propenal 
• 216572-80-4 (E)-3-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-propenal 
• 216572-78-0 3-(2-hydroxymethylphenyl)acrylic acid methyl ester 
• 52753-91-0 (E)-methyl 3-(2-formylphenyl)acrylate 

Relevant academic research and scientific papers

Regiocontrolled synthesis of cis-enediynes via intramolecular trapping of allytic cations

Trapping of allylic cations possessing 1,2-dialkynyl groups by an external nucleophile such as ROH yields cis-enediynes in a regioselective manner; while similar allylic cations react with an internal nucleophilic group to afford exclusively cis-enediynes. This regiocontrolled allylic rearrangement has been used successfully in the synthesis of a number of 2,5- dihydro-2-benzofuryl cis-enediynes 5 and the sulfur analogs.