216574-83-3Relevant academic research and scientific papers
Enantiopure trans- and cis-3-Aminoindan-1-ols: Preparation and application as novel basic resolving agents
Kinbara, Kazushi,Katsumata, Yoshiyuki,Saigo, Kazuhiko
, p. 266 - 267 (2007/10/03)
trans- and cis-3-Aminoindan-1-ols were prepared by moderately selective reductions of 3-aminoindan-1-one derivatives and separated into enantiopure forms. The enantiopure trans-isomer had a moderate resolving ability for 2-arylalkanoic acids having a naphthalene ring at the α-position. The X-ray crystallographic analysis showed that an infinite hydrogen-bond sheet was formed in the less-soluble salt, suggesting that the skeleton of these indanols would be favorable for the stabilization of the less-soluble salt by hydrogen-bonding interaction.
3-amino-1-indanole, method of synthesizing the same and method of optical resolution
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, (2008/06/13)
The present invention relates to a compound which is expected to be a synthetic intermediate for medicines and pesticides or a separating agent for chromatography or a enantiomerically resolving agent for racemic bodies. That is, it provides 3-amino-1-indanol represented by the formula (I), a process for synthesizing it, an enantiomerically active compound of 3-amino-1-indanol and a process for enantiomerically resolving 3-amino-1-indanol, and a separating agent for enantiomeric isomers comprising enantiomerically active compound thereof as an effective ingredient. In the formula, the configuration between OH group and NH2group are cis-configuration or trans-configuration and the compound may be a racemic body or an enantiomerically active compound.
