403672-04-8Relevant academic research and scientific papers
Enantiopure trans- and cis-3-Aminoindan-1-ols: Preparation and application as novel basic resolving agents
Kinbara, Kazushi,Katsumata, Yoshiyuki,Saigo, Kazuhiko
, p. 266 - 267 (2002)
trans- and cis-3-Aminoindan-1-ols were prepared by moderately selective reductions of 3-aminoindan-1-one derivatives and separated into enantiopure forms. The enantiopure trans-isomer had a moderate resolving ability for 2-arylalkanoic acids having a naphthalene ring at the α-position. The X-ray crystallographic analysis showed that an infinite hydrogen-bond sheet was formed in the less-soluble salt, suggesting that the skeleton of these indanols would be favorable for the stabilization of the less-soluble salt by hydrogen-bonding interaction.
