21659-40-5Relevant academic research and scientific papers
Reactions of Sulfonium Salts with 2,3-Dioxopyrrolidine Derivatives: A Concise Synthesis of Spirocyclopropane
Zhang, Shuang,Hu, Xiu-Qin,Wang, Zhu-Yin,Xu, Peng-Fei
, p. 2529 - 2537 (2015)
An efficient base-promoted spirocyclopropanation of 2,3-dioxopyrrolidine derivatives with sulfonium salts is described. This reaction enables a novel concise access to polysubstituted spirocyclopropane derivatives in good yields and with a trans/cis ratio of up to amp;gt;20:1 under mild conditions. amp;copy; Georg Thieme Verlag Stuttgart.
η6-Arene CH?O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams
Chen, Yong,Lin, Yicao,Luo, Zhonghua,Sun, Guodong,Wang, Zhongqing,Wu, Shuming,Zhang, Lei
, p. 3030 - 3034 (2021/06/01)
A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR-ATH) methodology of α-keto/enol-lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η6-arene CH?O interaction. The efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asymmetric reduction methods. (Figure presented.).
