216596-18-8

Basic information

• Product Name: Acetamide, 2-chloro-N-[1-(1,4-dihydro-4-oxo-2-quinazolinyl)ethyl]-N-(4-ethoxyphenyl )-
• CAS NO: 216596-18-8
• Molecular Formula: C20H20ClN3O3
• Molecular Weight: 385.85
• Mol File: 216596-18-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-chloro-N-[1-(1,4-dihydro-4-oxo-2-quinazolinyl)ethyl]-N-(4-ethoxyphenyl )-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-chloro-N-[1-(1,4-dihydro-4-oxo-2-quinazolinyl)ethyl]-N-(4-ethoxyphenyl )-(216596-18-8)
• EPA Substance Registry System: Acetamide, 2-chloro-N-[1-(1,4-dihydro-4-oxo-2-quinazolinyl)ethyl]-N-(4-ethoxyphenyl )-(216596-18-8)

Safety Data

• Hazardous Substances Data: 216596-18-8(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 143993-25-3 2-[1-(4-Ethoxy-phenylamino)-ethyl]-3H-quinazolin-4-one 
• 156-43-4 4-Ethoxyaniline 
• 144189-81-1 2-(1-bromoethyl)quinazolin-4(3H)-one 

Relevant articles and documents

Nitrogen Bridgehead Compounds Part 90. An Efficient Versatile Synthesis of 1-methyl-2-substituted 1,2,3,4-tetrahydro-6H-pyrazinoquinazoline-3,6-diones

A versatile synthesis of 2-substituted 1-methyl- and 1,4-dimethyl-1,2,3,4-tetrahydro-6H-pyrazinoquinazoline-3,6-diones is presented, starting from 2-(1-bromoethyl)quinazolin-4(3H)-one.The key step of the reaction sequence is the diastereoselective cyclization of 2-ethyl>quinazolin-4(3H)-ones.Usually 1,4-dimethyl derivatives are obtained as pure racemic cis-compounds (2-alkyl and 2-benzyl derivatives, or a mixture of diastereomers, containing the 4-methyl group in quasiaxial position.