2166-04-3

Basic information

• Product Name: Pyridazine, 3-(4-methoxyphenyl)-6-phenyl-
• CAS NO: 2166-04-3
• Molecular Formula: C17H14N2O
• Molecular Weight: 262.311
• Mol File: 2166-04-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyridazine, 3-(4-methoxyphenyl)-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridazine, 3-(4-methoxyphenyl)-6-phenyl-(2166-04-3)
• EPA Substance Registry System: Pyridazine, 3-(4-methoxyphenyl)-6-phenyl-(2166-04-3)

Safety Data

• Hazardous Substances Data: 2166-04-3(Hazardous Substances Data)

Upstream product

• 38111-44-3 phenylzinc(II) bromide 
• 58059-31-7 3-chloro-6-(4-methoxyphenyl)pyridazine 
• 144864-03-9 3-fluoro-6-phenylpyridazine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 70-11-1 α-bromoacetophenone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 183211-40-7 Thioacetic acid S-[(1Z,3Z)-4-acetylsulfanyl-1-(4-methoxy-phenyl)-4-phenyl-buta-1,3-dienyl] ester 
• 23061-52-1 3-(p-methoxyphenyl)-6-phenyl-1,2-dithiine 
• 183211-36-1 (1Z,3Z)-1-(4-Methoxy-phenyl)-4-phenyl-buta-1,3-diene-1,4-dithiol 
• 23429-36-9 1-methoxy-4-(phenylbuta-1,3-diynyl)benzene 
• 22867-08-9 (E)-1-(4-Methoxy-phenyl)-4-phenyl-but-2-ene-1,4-dione 
• 120-46-7 1,3-diphenylpropanedione 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 98-86-2 acetophenone 

Relevant articles and documents

B(C6F5)3-catalyzed metal-free hydrogenation of 3,6-diarylpyridazines

This paper describes the first metal-free hydrogenation of 3,6-diarylpyridazines, which was successfully realized using B(C6F5)3 as a catalyst. A variety of 1,4,5,6-tetrahydropyridazine derivatives were furnished in 85-95%

Highly selective mono-substitution in Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine with organozinc compounds

Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate

A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.