2166-04-3

Upstream product

• 70-11-1 α-bromoacetophenone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 144864-03-9 3-fluoro-6-phenylpyridazine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 18362-51-1 1,3-bis(4'-methoxyphenyl)propane-1,3-dione 
• 98-86-2 acetophenone 
• 6327-79-3 1-(4-methoxyphenyl)-3-phenylpropane-1,3-dione 
• 22867-08-9 (E)-1-(4-Methoxy-phenyl)-4-phenyl-but-2-ene-1,4-dione 
• 120-46-7 1,3-diphenylpropanedione 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 23198-91-6 (Z,Z)-1,4-di(benzylthio)-1-(p-methoxyphenyl)-4-phenyl-1,3-butadiene 
• 23429-36-9 1-methoxy-4-(phenylbuta-1,3-diynyl)benzene 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 38111-44-3 phenylzinc(II) bromide 

Relevant academic research and scientific papers

B(C6F5)3-catalyzed metal-free hydrogenation of 3,6-diarylpyridazines

This paper describes the first metal-free hydrogenation of 3,6-diarylpyridazines, which was successfully realized using B(C6F5)3 as a catalyst. A variety of 1,4,5,6-tetrahydropyridazine derivatives were furnished in 85-95%

Unexpected C-C bond cleavage: A route to 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from 1,3-dicarbonyl compounds and methyl ketones

An unexpected C-C bond cleavage has been revealed in the absence of metal. This observation has been exploited to develop an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple and commercially available 1,3-dicarbonyl compounds and methyl ketones.

Highly selective mono-substitution in Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine with organozinc compounds

Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

Cross-coupling reactions of phenylmagnesium halides with fluoroazines and fluorodiazines

The first nickel-catalyzed cross-coupling reactions between fluoroarenes and aryl organometallics using commercially available ligands are described. The nickel-catalyzed cross-coupling reactions between aryl Grignard reagents and fluoroazines and -diazin

Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate

A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.

1,2-Dithiines and precursors, XVI: Synthesis, structure, and reactivity of non-anellated 1,2-dithiines

Various monocyclic 1,2-dithiines 6a,b,d-t were prepared via (Z,Z)-1,4-difunctionalized butadienes (4-11,19,20). A twisted cyclic structure A is unequivocally proved rather than of the ringopened valence isomer B. The reactivity of these 1,2-dithiines is d