21663-56-9Relevant academic research and scientific papers
Synthesis and spectroscopic analysis of substituted 2-aminothiazolines
Ferreira, Renan B.,Tormena, Claudio F.,Almeida, Wanda P.
, p. 186 - 190 (2013/05/22)
2-Aminothiazolines can exist in two tautomeric species, amino and imino forms, which can theoretically exist as two stereoisomers. Several methods and techniques have been used to evaluate tautomeric process, but in this case 15N NMR spectrosco
A general and facile one-pot process of isothiocyanates from amines under aqueous conditions
Sun, Nan,Li, Bin,Shao, Jianping,Mo, Weimin,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
experimental part, p. 61 - 70 (2012/04/04)
A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS2 followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The choice of solvent is of decisive importance for the successful formation of the dithiocarbamate salt particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities.
