216661-54-0

Basic information

• Product Name: 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE
• Synonyms: 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE
• CAS NO: 216661-54-0
• Molecular Formula: C₁₉H₁₅N₃O
• Molecular Weight: 301.34
• Mol File: 216661-54-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.2g/cm³
• Refractive Index: 1.649
• CAS DataBase Reference: 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE(216661-54-0)
• EPA Substance Registry System: 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE(216661-54-0)

Safety Data

• Hazardous Substances Data: 216661-54-0(Hazardous Substances Data)

Usage

General Description

The chemical 6-(4-methoxy-phenyl)-3-phenyl-pyrazolo[1,5-a]pyrimidine is a heterocyclic compound with a pyrazolopyrimidine core and substituents of a methoxy-phenyl group and a phenyl group. It can be synthesized through various chemical reactions and is often used as a building block in the production of pharmaceuticals, agrochemicals, and materials science. 6-(4-METHOXY-PHENYL)-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE has potential applications in drug discovery and development due to its structural features, which can be targeted for specific biological activities. Its unique structure makes it a valuable molecule for research in medicinal chemistry and drug design.

InChI:InChI=1/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3

Upstream product

• 57999-06-1 4-phenyl-1H-pyrazol-5-amine 
• 65192-28-1 2-(4-methoxyphenyl)malondialdehyde 
• 140-29-4 phenylacetonitrile 
• 70205-70-8 2-dimethylaminomethylene-2-phenylacetonitrile 
• 53868-40-9 2-(4-methoxyphenyl)-3-malonaldehyde 

Downstream Products

• 515880-84-9 4-(3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-phenol 

Relevant articles and documents

Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization.

Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: A new class of KDR kinase inhibitors

We have synthesized and evaluated the activity of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines as a new class of KDR kinase inhibitors. Starting with screening lead 1, potency against isolated KDR was fully optimized with 3-thienyl and 4-methoxyphenyl substituents at the 6- and 3-positions (3g, KDR IC50=19 nM), respectively. The synthesis and SAR of these compounds are described.

Angiogenesis inhibitors

The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases/conditions such a