216699-35-3

Usage

Uses

Used in Biotechnology Industry:
5-CARBOXY-X-RHODAMINE TRIETHYLAMINE SALT, FOR FLUORESCENCE is used as a fluorescent label for oligonucleotide labeling and automated DNA sequencing applications. Its purified isomer form ensures accurate and reliable results in these applications.
Used in Research Applications:
In research, 5-CARBOXY-X-RHODAMINE TRIETHYLAMINE SALT, FOR FLUORESCENCE serves as a valuable tool for studying biological processes and interactions, particularly where fluorescence-based detection and imaging techniques are employed. Its unique properties allow for precise tracking and analysis of biomolecules in various experimental setups.

Upstream product

• 41175-50-2 8-hydroxyjulolidine 
• 552-30-7 trimellitic Anhydride 
• 536-90-3 m-Anisidine 

Downstream Products

• 209734-74-7 5-carboxy-X-rhodamine N-succinimidyl ester 

Relevant academic research and scientific papers

Compounds and Method for Imaging Cancer

A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.

METHODS FOR SYNTHESIZING RHODAMINE DYES

Described herein are methods for the regioselective synthesis of substituted rhodamine dyes.

Scalable Regioselective Synthesis of Rhodamine Dyes

A one-step, operationally simple protocol for the synthesis of isomerically pure rhodamine dyes from phthalaldehydic acids is reported. Using a mixture of 2,2,2-trifluoroethanol and water as reaction media allows for clean and efficient formation of vario

Synthesis of 5- and 6-carboxy-x-rhodamines

(Equation Presented) An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or y,y-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest.