21673-04-1Relevant articles and documents
Transition-Metal-Free [3 + 2] Cycloaddition of Nitroolefins and Diazoacetonitrile: A Facile Access to Multisubstituted Cyanopyrazoles
Chen, Zhen,Zhang, Yue,Nie, Jing,Ma, Jun-An
supporting information, p. 2120 - 2124 (2018/04/14)
A transition-metal-free [3 + 2] cycloaddition reaction between nitroolefins and diazoacetonitrile (N2CHCN) is described. This protocol exhibits several merits including simple starting materials, mild reaction conditions, broad substrate scope, good yields, and regioselectivities. The one-pot three-component reaction of nitroolefins with diazoacetonitrile (N2CHCN) and alkyl halides is also developed, thus delivering a series of multisubstituted cyanopyrazoles in good to high yields.
Synthesis of 3-cyanopyrazoles from 3-trifluoromethyl-pyrazoles via direct ammonolysis reaction
Yan, Tao,Chen, Yanhong,Wang, Jia,Xie, Yuyuan,Yang, Chunhao
experimental part, p. 431 - 439 (2012/03/09)
A simple and green method to prepare 3-cyanopyrazoles in aqueous ammonia from easy-obtained 3-trifluoromethyl-pyrazoles was explored. Most substrates got acceptable yields. The hydrogen position of N1-H on cyanopyrazoles was assigned by X-ray crystal structure analysis.
NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 41. LITHIUM TRIMETHYLSILYLDIAZOMETHANE. A NEW SYNTHON FOR THE PREPARATION OF PYRAZOLES FROM α,β-UNSATURATED NITRILES
Aoyama, Toyohiko,Inoue, Sumie,Shioiri, Takayuki
, p. 433 - 436 (2007/10/02)
Lithium trimethylsilyldiazomethane reacts smoothly with various α,β-unsaturated nitriles to give 3(or 5)-trimethylsilylpyrazoles in good yields.
