216766-12-0

Basic information

• Product Name: 6-(TRIFLUOROMETHYL)PYRIDIN-3-OL
• Synonyms: 3-Pyridinol, 6-(trifluoromethyl)-;6-(Trifluoromethyl)pyridin-3-ol;5-Hydroxy-2-(trifluoromethyl)pyridine;5-Hydroxy-2-(trifluoromethyl)p;6-Trifluoromethyl-3-pyridinol;2-(Trifluoromethyl)pyridin-5-ol, 6-(Trifluoromethyl)pyridin-3-ol;-Hydroxy-2-(trifluoromethyl)pyridine;6-((trifluoromethyl))-3-hydroxy-pyridine
• CAS NO: 216766-12-0
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.1
• EINECS: 1312995-182-4
• Product Categories: Pyridines
• Mol File: 216766-12-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 174-176℃
• Boiling Point: 286.7 °Cat760mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 1.423 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.96±0.18(Predicted)
• CAS DataBase Reference: 6-(TRIFLUOROMETHYL)PYRIDIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(TRIFLUOROMETHYL)PYRIDIN-3-OL(216766-12-0)
• EPA Substance Registry System: 6-(TRIFLUOROMETHYL)PYRIDIN-3-OL(216766-12-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 216766-12-0(Hazardous Substances Data)

Usage

Uses

6-(Trifluoromethyl)pyridin-3-ol is used in preparation of tricyclic dihydroimidazopyrimidone derivative as a lipoprotein-associated phospholipase A2 inhibitor.

Upstream product

• 436799-32-5 5-bromo-2(trifluoromethyl)pyridine 

Downstream Products

• 1159835-29-6 C₁₃H₁₄F₃NO₃ 
• 1369255-17-3 5-formyl-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile 
• 1369252-89-0 5-({[9-(methyloxy)-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-yl]oxy}methyl)-2-{[6-(trifluoromethyl)-3-pyridinyl]oxy}benzonitrile 
• 1369255-19-5 5-(hydroxymethyl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile 
• 216766-13-1 5-methoxy-2-(trifluoromethyl)pyridine 

Relevant articles and documents

Radical-anion coupling through reagent design: hydroxylation of aryl halides

The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Experimental and computational studies support the proposed radical-nucleophilic substitution chain mechanism.