436799-32-5

Basic information

• Product Name: 2-Trifluoromethyl-5-bromopyridine
• Synonyms: 5-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE;2-TRIFLUOROMETHYL-5-BROMOPYRIDINE;3-Bromo-6-(trifluoromethyl) pyridine;5-Bromo-2-(trifluoromethyl)pyridine 97%;5-Bromo-2-(trifluoromethyl)pyridine97%;TRIFLUOROMETHYL-5-BROMOPYRIDINE;TRIFLUOROMETHYL-5-BROMO-2-PYRIDINE;5-Bromo-alpha,alpha,alpha-trifluoro-2-picoline
• CAS NO: 436799-32-5
• Molecular Formula: C₆H₃BrF₃N
• Molecular Weight: 225.99
• Product Categories: blocks;Bromides;FluoroCompounds;Pyridines;Pyridine Series;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;Heterocyclic Compounds;Heterocycle;Building Blocks;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Fluorine series
• Mol File: 436799-32-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 44-46 °C
• Boiling Point: 68-70°C 10mm
• Flash Point: 174 °F
• Appearance: white crystal powder
• Density: 1.707 g/cm³
• Vapor Pressure: 1.3mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.80±0.22(Predicted)
• CAS DataBase Reference: 2-Trifluoromethyl-5-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Trifluoromethyl-5-bromopyridine(436799-32-5)
• EPA Substance Registry System: 2-Trifluoromethyl-5-bromopyridine(436799-32-5)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-37-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 436799-32-5(Hazardous Substances Data)

Usage

Chemical Properties

white crystal powder

Uses

Regioselective C-4 deprotonation with LDA and trapping with carbon dioxide leads to the corresponding C-4 acid.

InChI:InChI=1/C6H3BrF3N/c7-4-1-2-5(11-3-4)6(8,9)10/h1-3H

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 223463-13-6 2-iodo-5-bromopyridine 
• 624-28-2 2,5-dibromopyridine 

Downstream Products

• 867256-50-6 4-(6-trifluoromethyl-pyridin-3-yl)-benzoic acid methyl ester 
• 868662-36-6 6-(trifluoromethyl)-3-pyridinylboronic acid 
• 1218790-39-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine 
• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 1600499-05-5 2-(4-fluorophenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 1599530-87-6 (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1555700-97-4 7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-4-(6-(trifluoromethyl)pyridin-3-yl)indoline 
• 1450819-71-2 N-[4-chloro-2-[1-[6-(trifluoromethyl)-3-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide 
• 1441144-18-8 3-[[3-[[4-chloro-2-[1-[6-(trifluoromethyl)-3-pyridyl]pyrazole-4-carbonyl]phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid 
• 1428798-65-5 C₁₈H₁₂F₆N₄ 
• 1422386-73-9 N-(N-(((tert-butyl)oxy)carbonyl)-S-phenylsulfonimidoyl)-6-(trifluoromethyl)nicotinamide 
• 1417724-06-1 (2-methoxyphenyl)bis(6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1417724-04-9 (2-chlorophenyl)(6-(trifluoromethyl)pyridin-3-yl)methanol 
• 1417724-02-7 diphenyl(6-(trifluoromethyl)pyridin-3-yl)methanol 

Relevant articles and documents

Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach

MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.

NOVEL GPR119 AGONIST COMPOUNDS

The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.