2168-88-9Relevant academic research and scientific papers
3,3′-selenobis(propionic acid)
Doudin, Khaled I.,Songstad, Jon,Toernroos, Karl W.
, p. 439 - 440 (2001)
In contrast to Se[CH2C(O)OH]2 versus S[CH2C(O)OH]2, the title compound, Se[CH2CH2C(O)OH]2 or C6H10O4Se, is structurally quite similar to its sulfur analogue. The molecule has twofold symmetry. The C-Se-C bond anogle is 96.48 (8)° and the Se-C bond lengths are 1.9610 (14) A. The shortest Se···O intermolecular distance is 3.5410 (11) A. The O···O distances in the carboxylic acid dimers are 2.684 (2) A. The temperature dependence of the IR spectrum suggests tautomerism in the solid state.
Applications of water-soluble selenides and selenoxides to protein chemistry
Iwaoka, Michio,Kumakura, Fumio
, p. 1009 - 1017 (2008)
Two water-soluble organic selenides, 3,3'-selenodipropanonic acid and 2-selenanecarboxylic acid, were synthesized and reversibly converted to the corresponding selenoxides in deuterium oxide by the sequential treatment with stoichiometric amounts of hydrogen peroxide and then dithiothreitol. The antioxidative catalytic activity of 3,3'-selenodipropanonic acid was subsequently investigated by NMR spectroscopy in the reaction of hydrogen peroxide with dithiothreitol, cysteamine, and benzyl mercaptan in deuterated methanol. For all thiol substrates, the selenide exhibited the distinct catalytic activity. However, the activity was remarkably higher for the dithiol substrate (i.e., dithiothreitol). These results suggested that water-soluble selenides are good glutathione peroxidase mimics, in particular when polythiols are employed as the substrate. It was also suggested that water-soluble selenoxides are efficient oxidizing reagents for protein disulfide-bond formation.
