216868-37-0Relevant academic research and scientific papers
Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth
Wrona, Iwona E.,Lowe, Jason T.,Turbyville, Thomas J.,Johnson, Tanya R.,Beignet, Julien,Beutler, John A.,Panek, James S.
supporting information; experimental part, p. 1897 - 1916 (2009/07/01)
Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1-C13 tetrahydropyran fragment of the molecule were prepared utilizing crotylsilane reagents 9 and 10 in our
Total synthesis of bistramide A
Lowe, Jason T.,Wrona, Iwona E.,Panek, James S.
, p. 327 - 330 (2007/10/03)
(Chemical Equation Presented) An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product.
An efficient protocol for the stereoselective dihydroxylation of ene- ester systems
Hermitage, Stephen A.,Murphy, Alison,Nielsen, Poul,Roberts, Stanley M.
, p. 13185 - 13202 (2007/10/03)
Dihydroxylation of ene ester systems was achieved in good yield and diastereoselectivity under classical catalytic OsO4 and NMO conditions using the intrinsic diastereoselectivity in α-methyl β-OTBS systems. This intrinsic diastereoselection ca
