927396-39-2Relevant academic research and scientific papers
Synthesis of the C8-C16 fragment of amphidinolide R
Reddy, Chada Raji,Ramesh, Palacherla,Rao, Nagavaram Narsimha
, p. 1532 - 1536 (2014)
An asymmetric synthesis of the C8-C16 fragment with several stereogenic centers of amphidinolide R, is described. The key reaction, Sharpless asymmetric epoxidation has provided the basis for generation of the required stereocenters. The target fragment was accomplished in a convergent manner in nine steps (longest linear synthesis of the sequence) and 32% overall yield was obtained starting from 2-butene-1,4-diol.
Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth
Wrona, Iwona E.,Lowe, Jason T.,Turbyville, Thomas J.,Johnson, Tanya R.,Beignet, Julien,Beutler, John A.,Panek, James S.
supporting information; experimental part, p. 1897 - 1916 (2009/07/01)
Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1-C13 tetrahydropyran fragment of the molecule were prepared utilizing crotylsilane reagents 9 and 10 in our
Total synthesis of bistramide A
Lowe, Jason T.,Wrona, Iwona E.,Panek, James S.
, p. 327 - 330 (2007/10/03)
(Chemical Equation Presented) An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product.
