216979-79-2

Upstream product

• 484-11-7 2.9-dimethyl-1,10-phenanthroline 
• 100-53-8 phenylmethanethiol 
• 34302-69-7 2,9-dimethyl-1,10-phenanthroline monohydrate 

Downstream Products

• 729572-78-5 (2,9-dimethylphenanthroline) zinc o-bis(mercaptomethyl)benzoate 
• 3492-64-6 sodium benzylmercaptide 
• 729572-82-1 (2,9-dimethylphenanthroline) zinc iodide benzylmercaptonate 
• 729572-87-6 (2,9-dimethylphenanthroline) zinc iodide S(o-CH₂C₆H₄CH₂)SCH₂C₆H₅ 
• 729572-90-1 (2,9-dimethylphenanthroline) zinc benzylmercaptonate methyl sulfate 

Relevant academic research and scientific papers

(Neocuproin)zinc Thiolates: Attempts at Modeling Cobalamin-Independent Methionine Synthase

Several new complexes [(neo)Zn(SR)2] [neo = neocuproin (2,9-dimethylphenanthroline)] have been synthesized and structurally characterised. They react in a stepwise fashion with the alkylating agents CH3I and (CH3)2SO4 to afford the thioethers CH3SR and first the mixed complexes [(neo)Zn(SR)X] (X = I, CH3SO4) and then [(neo)ZnX2]. Similar alkylations occur with benzyl iodide, but not with trimethyl phosphate in nonpolar media. Under these conditions, thiolate exchange with [PPN]SR does not occur which indicates that the alkylations take place at the zinc-bound thiolates. In polar solvents (methanol, DMSO), thiolate exchange occurs readily, and at higher temperatures (CH3)3PO4 also acts as an alkylating agent which indicates that under these conditions free thiolate is available in solution. Qualitative kinetic data support the associative alkylation mechanism in nonpolar media and the change of mechanism in polar media. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Zinc thiolate complexes with chelating nitrogen ligands

The thiolates SPh-, SCH2Ph- and SCH2CH2Ph- were combined with polydentate nitrogen donor ligands in monomeric zinc complexes. N-substituted bis(benzimidazolylmethyl)sulfides (R-BIMS) yielded the complexes (R-BIMS)Zn(SR)2 (1-3) in which the central thioether sulfur does not coordinate. This holds also for the o-hydroxymethyl-thiophenolate complex (4). 2,9-Dimethylphenanthroline (neocuproin, NEO) produced compounds (NEO)Zn(SR)2 (5). Bis(dimethylpyrazolyl-N-ethyl)amine (PEA) led to (PEA)Zn(SPh)2 (6) in which only one pyrazole nitrogen and the central amine nitrogen are coordinated. 2-Mercaptomethylpyridine (HMMP) formed the bis-ligand complex (MMP)2Zn (7). Six structure determinations have shown that all complexes are characterized by a tetrahedral ZnN2S2 coordination, irrespective of the ring size (5,6, 8) which is thereby enforced on the chelate ligand, even at the expense of unused ligand donor atoms.