216985-39-6Relevant academic research and scientific papers
Neutral inhibitors of the serine protease factor Xa
Shrader, William D.,Young, Wendy B.,Sprengeler, Paul A.,Sangalang, Joan C.,Elrod, Kyle,Carr, Grant
, p. 1801 - 1804 (2001)
A neutral inhibitor of the serine protease factor Xa was identified via a high-throughput screen of a commercial library. The initial lead 1 demonstrated reversible and competitive inhibition kinetics for factor Xa and possessed a high degree of selectivity versus other related serine proteases. Initial modeling efforts and the generation of a series of analogues of 1 are described.
