2170608-82-7 Usage
Uses
Used in Pharmaceutical Research:
6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile is utilized as a research compound for its potential applications in the development of new pharmaceuticals. The presence of the carbonitrile group and the isopropylphenyl moiety may endow the compound with specific biological activities, which can be explored for therapeutic purposes.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile serves as a starting point for the design and synthesis of novel drug candidates. Its complex structure allows for modifications and optimizations that could lead to the discovery of new therapeutic agents with improved efficacy and selectivity.
Used in Drug Development:
6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile is employed in drug development as a lead compound. Its unique structural features provide a foundation for further exploration and refinement, with the aim of identifying potential drug candidates that can be advanced through preclinical and clinical stages of development.
Used in Chemical Synthesis:
In the realm of chemical synthesis, 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile is used as a building block or intermediate in the synthesis of more complex molecules. Its versatile structure allows for various synthetic routes and transformations, facilitating the creation of new compounds with diverse properties and applications.
Used in Biological Assays and Screening:
6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile is utilized in biological assays and high-throughput screening processes to evaluate its potential as a bioactive molecule. These assays can provide valuable insights into the compound's interactions with biological targets, such as enzymes, receptors, or cellular pathways, guiding its further development as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 2170608-82-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,7,0,6,0 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2170608-82:
(9*2)+(8*1)+(7*7)+(6*0)+(5*6)+(4*0)+(3*8)+(2*8)+(1*2)=147
147 % 10 = 7
So 2170608-82-7 is a valid CAS Registry Number.
2170608-82-7Relevant academic research and scientific papers
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators
Sharma, Lalit Kumar,Yun, Mi Kyung,Subramanian, Chitra,Tangallapally, Rajendra,Jackowski, Suzanne,Rock, Charles O.,White, Stephen W.,Lee, Richard E.
, (2021/11/24)
Pantothenate kinase (PANK) is the critical regulator of intracellular levels of coenzyme A and has emerged as an attractive target for treating neurological and metabolic disorders. This report describes the optimization, synthesis, and full structure–activity relationships of a new chemical series of pantothenate competitive PANK inhibitors. Potent drug-like molecules were obtained by optimizing a high throughput screening hit, using lipophilic ligand efficiency (LipE) derived from human PANK3 IC50 values to guide ligand development. X-ray crystal structures of PANK3 with index inhibitors from the optimization were determined to rationalize the emerging structure activity relationships. The analysis revealed a key bidentate hydrogen bonding interaction between pyridazine and R306′ as a major contributor to the LipE gain observed in the optimization. A tractable series of PANK3 modulators with nanomolar potency, excellent LipE values, desirable physicochemical properties, and a well-defined structural binding mode was produced from this study.
