35857-89-7

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-3-pyridazinecarbonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Synthesis of Stearoyl-CoA Desaturase-1 Inhibitors:
6-Chloro-3-pyridazinecarbonitrile is used as a reactant in the synthesis of spiropiperidine-based stearoyl-CoA desaturase-1 (SCD-1) inhibitors. SCD-1 is an enzyme involved in the synthesis of monounsaturated fatty acids, and its inhibition can have potential applications in the treatment of metabolic disorders such as obesity and diabetes. The incorporation of 6-chloro-3-pyridazinecarbonitrile into the molecular structure of these inhibitors contributes to their biological activity and selectivity towards the target enzyme.

InChI:InChI=1/C5H2ClN3/c6-5-2-1-4(3-7)8-9-5/h1-2H

Upstream product

• 60184-73-8 6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid amide 
• 66346-83-6 3-Chloro-pyridazine-6-carboxamide 
• 37972-69-3 6-oxo-1,6-dihydropyridazine-3-carboxylic acid 
• 135034-10-5 3-chloro-6-iodopyridazine 
• 544-92-3 copper(I) cyanide 
• 6531-04-0 6-chloro-pyridazine-3-carbonyl chloride 

Downstream Products

• 152913-00-3 3-p-chlorobenzoyl-6-chloropyridazine 
• 49542-03-2 3-Hydrazino-6-cyano-pyridazin 
• 252320-85-7 3-(4-(4-(6-Cyano-3-pyridazinyl)piperazin-1-yl)-3-fluorophenyl)-5(R)-hydroxy methyloxazolidin-2-one 
• 1032714-02-5 6-[1-(3,5-difluoro-benzyl)-piperidin-4-ylamino]-pyridazine-3-carbonitrile 
• 1032714-06-9 6-[1-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-ylamino]-pyridazine-3-carbonitrile 
• 1032714-08-1 6-[1-(3,4,5-trifluoro-benzyl)-piperidin-4-ylamino]-pyridazine-3-carbonitrile 
• 1032714-04-7 6-[1-(3-trifluoromethyl-benzyl)-piperidin-4-ylamino]-pyridazine-3-carbonitrile 
• 1441876-84-1 6-(benzylamino)-N-hydroxypyridazine-3-carboximidamide 
• 1441874-17-4 N-benzyl-6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridazin-3-amine 
• 1441876-79-4 6-(benzylamino)pyridazine-3-carbonitrile 
• 69579-17-5 3-[(6-carbamoyl-pyridazin-3-yl)-hydrazono]-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical com

PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS

The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors

Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin

Aromatic compounds and pharmaceutical compositions containing them

The invention relates to compounds of formula I and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof and processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

Fungicidal pyridazines

Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is

Synthesis and antihypertensive activity of novel 6-substituted-3-pyridazinylhydrazones

The synthesis and hypotensive properties of a series of 6-substituted-3-pyridazinylhydrazones are described. The most active compound of the series. 1-(6-morpholino-3-pyridazinyl)-2-[1-(tert-butoxycarbonyl)-2-propylidene] hydrazine, is a more potent hypotensive agent than hydralazine with a longer duration of action and a lower toxicity. Structure-activity relationships are discussed.