217074-38-9

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 217074-34-5 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(2-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 

Downstream Products

• 180477-15-0 2-(N,N-diphenylcarbamoyl)oxy-9-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-9H-purine 
• 180477-13-8 2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine 

Relevant academic research and scientific papers

Thermal stability studies of the non canonical base pair between 5- methyl-isocytosine and isohypoxanthine

The hybridization properties of 5-methyl-isocytosine ((5Me)isoC) and isohypoxanthine (isoI) have been investigated by using ultraviolet melting techniques. These two bases were incorporated into heptadecanucleotides using the phosphoramidite chemistry. The base pair (5Me)isoC/isoI was found to be isoenergetic with the A/T base pair. A small destabilization was observed when isoI was located opposite T or G and can be interpreted by a pairing mode between these bases and isol in its lactam form.