Thermal stability studies of the non canonical base pair between 5- methyl-isocytosine and isohypoxanthine

DOI: 10.1016/S0040-4020(98)00820-5

Source and publish data:

Tetrahedron p. 13547 - 13556 (1998)

Update date:2022-07-31

Topics:

Authors:

Beaussire, Jean-Jacques

Pochet, Sylvie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(98)00820-5

The hybridization properties of 5-methyl-isocytosine ((5Me)isoC) and isohypoxanthine (isoI) have been investigated by using ultraviolet melting techniques. These two bases were incorporated into heptadecanucleotides using the phosphoramidite chemistry. The base pair (5Me)isoC/isoI was found to be isoenergetic with the A/T base pair. A small destabilization was observed when isoI was located opposite T or G and can be interpreted by a pairing mode between these bases and isol in its lactam form.

Full text of DOI:10.1016/S0040-4020(98)00820-5

Products guided by the article

Product name:(2R,3S,5R)-2-Hydroxymethyl-5-{2-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-ol

Cas No:217074-38-9

R&D Labs maybe for 217074-38-9

Oceachem Group Limited

website:http://www.oceanchem-group.com

Contact:86-536-8596048

Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Jining tiansheng chemical co.,ltd.

Contact:+86-537-5158722

Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
Wuxi Forest Biological Co.,Ltd

Contact:+86-510-81602300

Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Chemsky（shanghai）International Co.,Ltd.

Contact:0

Address:0
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park

Relevant to this article

Stereocontrolled preparation of cis- and trans-2,6-dialkylpiperidines via diastereoselective reaction of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives with Grignard reagents

Doi:10.1016/S0040-4020(98)00863-1
(1998)
Doi:10.1039/j39690000559
(1969)
Doi:10.1021/jo01100a627
(1958)
Doi:10.1007/BF00522590
()
Importance of the proximity and orientation of ligand-linkage to the design of cinnamate-GW9662 hybrid compounds as covalent PPAR agonists

Doi:10.3390/molecules24102019
(2019)
De novo design of a novel oxazolidinone analogue as a potent and selective α(1A) adrenergic receptor antagonist with high oral bioavailability

Doi:10.1021/jm000085e
(2000)

Article Doi