Thermal stability studies of the non canonical base pair between 5- methyl-isocytosine and isohypoxanthine

DOI: 10.1016/S0040-4020(98)00820-5

Source and publish data:

Tetrahedron p. 13547 - 13556 (1998)

Update date:2022-07-31

Topics:

Authors:

Beaussire, Jean-Jacques

Pochet, Sylvie

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Article abstract of DOI:10.1016/S0040-4020(98)00820-5

The hybridization properties of 5-methyl-isocytosine ((5Me)isoC) and isohypoxanthine (isoI) have been investigated by using ultraviolet melting techniques. These two bases were incorporated into heptadecanucleotides using the phosphoramidite chemistry. The base pair (5Me)isoC/isoI was found to be isoenergetic with the A/T base pair. A small destabilization was observed when isoI was located opposite T or G and can be interpreted by a pairing mode between these bases and isol in its lactam form.

Full text of DOI:10.1016/S0040-4020(98)00820-5

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