217090-26-1

Basic information

• Product Name: benzyl-(1-pyridin-2-yl-but-3-enyl)-amine
• Synonyms: benzyl-(1-pyridin-2-yl-but-3-enyl)-amine
• CAS NO: 217090-26-1
• Molecular Weight: 238.332
• Mol File: 217090-26-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl-(1-pyridin-2-yl-but-3-enyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-(1-pyridin-2-yl-but-3-enyl)-amine(217090-26-1)
• EPA Substance Registry System: benzyl-(1-pyridin-2-yl-but-3-enyl)-amine(217090-26-1)

Safety Data

• Hazardous Substances Data: 217090-26-1(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 19198-87-9 N-[(1E)-pyridin-2-ylmethylidene]benzenemethanamine 
• 106-95-6 allyl bromide 

Relevant articles and documents

An improved and stereoselective route to all-cis-2,6-disubstituted 4-hydroxypiperidines from accessible 4-substituted 4-N-benzylaminobut-1-enes

The reaction between allylmagnesium bromide and imines 5a-l leads to the corresponding 4-substituted 4-N-benzylaminobut-1-enes 6a-1, which were oxidized in a regioselective manner to the alkenylnitrones 7a-l. The intramolecular 1,3-dipolar cycloaddition of these nitrones gave 2-spiroannulated or 2-substituted 6-exo-phenyl-1-aza-7-oxabicyclo[2.2.1]heptanes 8a-j. Reductive cleavage of the N-O bond of the obtained bicycles afforded the diverse substituted 4-hydroxypiperidines 9a-h in good yields. This stereoselective approach allowed the preparation of all-cis-4-hydroxy-6-phenyl-2-nonylpiperidine (9i), a close analogue of dendrobatid frog alkaloid 241D.