21713-52-0

Upstream product

• 1707-03-5 diphenyl-phosphinic acid 
• 108-39-4 3-methyl-phenol 
• 829-85-6 diphenylphosphane 
• 32578-31-7 3-tolyl triflate 
• 4559-70-0 Diphenylphosphine oxide 

Relevant academic research and scientific papers

Electrochemical Enabled Cascade Phosphorylation of N?H/O?H/S?H Bonds with P?H Compounds: An Efficient Access to P(O)-X Bonds

An electrochemical three component cascade phosphorylation reaction of various heteroatoms-containing nucleophiles including carbazoles, indoles, phenols, alcohols, and thiols with Ph2PH has been established. Electricity is used as the “traceless” oxidant and water and air are utilized as the “green” oxygen source. All kinds of structurally diverse organophosphorus compounds with P(O)-N/P(O)-O/P(O)-S bonds are assembled in moderate to excellent yields (three categories of phosphorylation products, 50 examples, up to 97 % yield). A tentative free radical course is put forward to rationalize the reaction procedure.

Base-promoted selective O-phosphorylation of aryl triflates with P(O)-H compounds

Compared to previous transition metal-catalyzed C-phosphorylation reactions for constructing C–P bonds, in the absence of transition metal catalysts and ligands, a direct O-phosphorylation of aryl triflates selectively occurred with P(O)-H compounds in the presence of a base via the construction of O–P bonds. This transformation proceeds under simple and mild conditions, and provides a new method for the preparation of valuable organophosphoryl compounds from readily available P(O)-H compounds and triflates.

Phosphonate compound, preparation method and application thereof

The invention provides a phosphonate compound, a preparation method and application thereof. The method includes the steps of: in a nitrogen atmosphere, mixing a P(O)-H compound, an aryl trifluoromethanesulfonate compound, an alkali reagent and an organic solvent, carrying out stirring reaction at 80-130DEG C for 15-24h, and conducting cooling, washing and extraction at the end of reaction to obtain an organic phase; drying and distilling the obtained organic phase to obtain the phosphonate compound; wherein the molar ratio of the P(O)-H compound, the aryl trifluoromethanesulfonate compound and the alkali reagent is 1-3:1:2-3. The method has the advantages of simple and easily available raw materials, simple reaction conditions, wide functional group compatibility, high yield and wide applicability, the structural formula of the obtained phosphonate compound is shown as formula (I) in the specification, and the extraction rate of the phosphonate compound applied to the field of lithiumion extraction is 53% or above.

DCC-assisted direct esterification of phosphinic and phosphoric acids with O-nucleophiles

A novel and efficient dicyclohexylcarbodiimide-promoted protocol for the selective and controllable esterification of P(O)OH compounds using O-nucleophiles (alcohols and phenols) as efficient esterification reagents is described. This method features a high efficiency and good functional-group tolerance, meaning a simple way to synthesize a broad spectrum of phosphinic and phosphoric acid esters from basic starting materials with moderate to excellent yields.

Method for preparing organophosphate compound through efficient esterification of P(O)-OH-containing compound and phenol

The invention provides a method for preparing an organophosphate compound through efficient esterification of a P(O)-OH-containing compound and phenol. The method realizes efficient and highly selective synthesis of organophosphate derivatives containing

CDI-promoted direct esterification of P(O)-OH compounds with phenols

A novel and efficient N,N′-carbonyl diimidazole-catalyzed protocol for the direct esterification of P(O)-OH compounds using phenols as efficient esterification reagents is illustrated. It is a simple way to synthesis a broad spectrum of functionalized O-aryl phosphinates, phosphonates, and phosphates from basic starting materials with moderate to excellent yields.

Copper-catalyzed direct esterification of P(O)-OH compounds with phenols

A novel copper-catalyzed method for the direct esterification of P(O)-OH compounds using phenols as efficient esterification reagents is illustrated. It is a simple way to generate a broad spectrum of functionalized O-aryl phosphinates, phosphonates, and phosphates from basic starting materials with moderate to excellent yields.