21714-35-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-CHLORO-5-TRIFLUOROMETHYL)PHENYLTHIOUREA is used as a pharmaceutical agent for its anti-inflammatory, antitumor, and antimicrobial properties. It has demonstrated promising effects in various research studies, making it a candidate for the development of new drugs to treat a range of conditions.
Used in Agrochemical Industry:
In the agrochemical field, (2-CHLORO-5-TRIFLUOROMETHYL)PHENYLTHIOUREA is utilized as a bioactive compound for its potential to control pests and diseases in agriculture. Its antimicrobial properties can contribute to the development of new pesticides or fungicides.
Used in Enzyme Inhibition Research:
(2-CHLORO-5-TRIFLUOROMETHYL)PHENYLTHIOUREA is employed as an enzyme inhibitor in research studies. Its inhibitory effect on certain enzymes can provide insights into the development of new therapeutic agents or the understanding of enzyme functions in biological systems.
Used in Photochromic Material Development:
(2-CHLORO-5-TRIFLUOROMETHYL)PHENYLTHIOUREA is also used as a potential photochromic material. Its ability to change color upon exposure to light can be harnessed for various applications, such as smart windows, optical data storage, or sensors.
Overall, (2-CHLORO-5-TRIFLUOROMETHYL)PHENYLTHIOUREA is a versatile compound with a wide range of potential applications in chemistry and biology, from pharmaceuticals and agrochemicals to enzyme research and photochromic material development.

InChI:InChI=1/C8H6ClF3N2S/c9-5-2-1-4(8(10,11)12)3-6(5)14-7(13)15/h1-3H,(H3,13,14,15)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 89069-95-4 N-(2-chloro-5-(trifluoromethyl)phenylcarbamothioyl)benzamide 

Downstream Products

• 1320341-51-2 C₁₆H₉ClF₃N₃O₂S 
• 21714-36-3 N-(2-chloro-5-(trifluoromethyl)phenyl)cyanamide 

Relevant academic research and scientific papers

N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl- d -aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships

N-Methyl-d-aspartate (NMDA) receptor dysfunction has been linked to several neuropsychiatric disorders, including Alzheimer's disease, epilepsy, drug addiction, and schizophrenia. A radioligand that could be used with PET to image and quantify human brain NMDA receptors in the activated "open channel" state would be useful for research on such disorders and for the development of novel therapies. To date, no radioligands have shown well-validated efficacy for imaging NMDA receptors in human subjects. In order to discover improved radioligands for PET imaging, we explored structure-affinity relationships in N′-3-(trifluoromethyl)phenyl derivatives of N-aryl-N′-methylguanidines, seeking high affinity and moderate lipophilicity, plus necessary amenability for labeling with a positron-emitter, either carbon-11 or fluorine-18. Among a diverse set of 80 prepared N′-3-(trifluoromethyl)phenyl derivatives, four of these compounds (13, 19, 20, and 36) displayed desirable low nanomolar affinity for inhibition of [3H](+)-MK801 at the PCP binding site and are of interest for candidate PET radioligand development.

Regioselective one-pot synthesis of 5-CHLORO-3-METHYL8-TRIFLUOROMETHYL-4H- l,4-BENZOTHIAZINES

5-Chloro-3-methyl-8-trifluoromethyl-4H-l, 4-benzothiazines have been synthesized by an efficient synthetic method in a single step involving heterocyclization of 2amino-3-chloro-6-trifluoromethylbenzenethiol with D-ketoesters or D-diketones. 2Amino-3-chloro-6-trifluoromethylbenzenethiol was prepared by hydrolytic cleavage of 2-amino-4-chloro-7- trifluoromethylbenzothiazole which in turn was prepared by brominative cyclization of 2-chloro-5-trifluoromethylphenylthiourea. The phenylthiourea was prepared by the reaction of 2-chloro-5-trifluoromethylaniline with ammonium thiocyantate. The structures of the synthesized 4H-1,4-benzothiazines have been characterized by their elemental analyses and spectral characteristics.