21717-91-9Relevant academic research and scientific papers
Discovery of triazines as potent, selective and orally active PDE4 inhibitors
Gewald, Rainer,Grunwald, Christian,Egerland, Ute
, p. 4308 - 4314 (2013/07/25)
Expanding on HTS hit 4 afforded a series of [1,3,5]triazine derivatives as novel PDE4 inhibitors. The SAR development and optimization process with the emphasis on ligand efficiency and physicochemical properties led to the discovery of compound 44 as a potent, selective and orally active PDE4 inhibitor.
