217173-96-1

Basic information

• Product Name: (2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane
• Synonyms: (2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane
• CAS NO: 217173-96-1
• Molecular Weight: 366.413
• Mol File: 217173-96-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane(217173-96-1)
• EPA Substance Registry System: (2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane(217173-96-1)

Safety Data

• Hazardous Substances Data: 217173-96-1(Hazardous Substances Data)

Upstream product

• 5055-10-7 (2S)-2-hydroxy-1,4-bis<(methansulfonyl)oxy>butane 
• 65-85-0 benzoic acid 

Downstream Products

• 316824-52-9 (2S,3R,3aS,4R)-4-benzoyloxy-2,3-bis(methoxycarbonyl)hexahydropyrrolo[1,2-b]isoxazole 
• 217173-97-2 (3R)-3-benzyloxy-1-pyrroline 1-oxide 
• 158146-78-2 (-)-(1S,6R,6aS,7R)-6-(Benzoyloxy)-7-carbomethoxy-1-hydroxyhexahydro-1H-pyrrolizin-2-one 

Relevant articles and documents

Cycloaddition of an enantiopure cyclic nitrone to maleate: Straightforward synthesis of the necine base (-)-hastanecine

A formal synthesis of the necine base (-)-hastanecine, subunit of the pyrrolizidine alkaloids hastacine and punctanecine, is reported. The key intermediate 7 is synthesized in five steps from dimesylate 11, derived from L-malic acid, in 28.3% overall yield. The correct absolute stereochemistry at C7 in the target compound is attained by means of a Mitsunobu reaction on dimesylate 11. The desired stereochemistry at the remaining stereogenic centres (C1 and C7a) derives from a highly preferential exo-anti approach in the key cycloaddition of nitrone 9 (obtained with complete regiocontrol) to dimethyl maleate.