217178-61-5Relevant academic research and scientific papers
Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives
Venkatachalam,Tai, Hung-Liang,Vig, Rakesh,Chen, Chun-Lin,Jan, Shyi-Tai,Uckun, Fatih M.
, p. 3121 - 3126 (1998)
d4T-5'-[p-Bromophenyl methoxyalaninyl phosphate] (d4T-pBPMAP), a novel phenyl phosphate derivative of 2',3'-didehydro-2',3'-dideoxythymidine (d4T) that has an enhanced ability to undergo hydrolysis due to the electron withdrawing properties of its single
One-pot synthesis of aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
Jiang, Peng,Guo, Xin,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
, p. 2537 - 2539 (2007/10/03)
Arbuzov reaction of aryl phosphorodichloridite with mixture of one equivalent of AZT or d4T and one equivalent of tert-butyl alcohol led to the corresponding AZT/d4T aryl H-phosphonate diesters, and the following reaction of the H-phosphonate diesters wit
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship
Siddiqui, Adam Q.,Ballatore, Carlo,McGuigan, Christopher,De Clercq, Erik,Balzarini, Jan
, p. 393 - 399 (2007/10/03)
New substituted-aryl phosphoramidate derivatives of the anti-HIV drug d4T were synthesized as membrane-soluble intracellular prodrugs for the free bioactive phosphate to establish relationship(s) between compound structure and in vitro antiviral activity.
