Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives

DOI: 10.1016/S0960-894X(98)00547-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3121 - 3126 (1998)

Update date:2022-08-03

Topics:

Authors:

Venkatachalam

Tai, Hung-Liang

Vig, Rakesh

Chen, Chun-Lin

Jan, Shyi-Tai

Uckun, Fatih M.

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Article abstract of DOI:10.1016/S0960-894X(98)00547-2

d4T-5'-[p-Bromophenyl methoxyalaninyl phosphate] (d4T-pBPMAP), a novel phenyl phosphate derivative of 2',3'-didehydro-2',3'-dideoxythymidine (d4T) that has an enhanced ability to undergo hydrolysis due to the electron withdrawing properties of its single

Full text of DOI:10.1016/S0960-894X(98)00547-2

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