217178-62-6Relevant academic research and scientific papers
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: Structural determinants for in vitro activity and QSAR
Siddiqui, Adam Q.,McGuigan, Christopher,Ballatore, Carlo,Zuccotto, Fabio,Gilbert, Ian H.,De Clercq, Erik,Balzarini, Jan
, p. 4122 - 4128 (1999)
A series of new substituted-aryl phosphoramidate derivatives of the anti-HIV drug d4T were synthesized as membrane-soluble nucleotide prodrugs, to extend and quantify the SAR observed for an earlier series of related derivatives. All of the compounds were
Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine)
Venkatachalam, Taracad K.,Qazi, Sanjive,Uckun, Fatih M.
, p. 152 - 158 (2007/10/03)
The distereoisomers of stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyi)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6) were separated using two different procedures. The first method involved separation of the iso
Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent
DuMez, Darin,Venkatachalam, Taracad K.,Uckun, Fatih M.
, p. 136 - 151 (2007/10/03)
The arylphosphoramidate derivative of stavudine (STV, d4T, 2',3'-didehydro-3'-deoxythymidine, CAS 3056-17-5), stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6), is a n
Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives
Venkatachalam,Tai, Hung-Liang,Vig, Rakesh,Chen, Chun-Lin,Jan, Shyi-Tai,Uckun, Fatih M.
, p. 3121 - 3126 (2007/10/03)
d4T-5'-[p-Bromophenyl methoxyalaninyl phosphate] (d4T-pBPMAP), a novel phenyl phosphate derivative of 2',3'-didehydro-2',3'-dideoxythymidine (d4T) that has an enhanced ability to undergo hydrolysis due to the electron withdrawing properties of its single
