217090-42-1

Basic information

• Product Name: L-Alanine, N-[(4-bromophenoxy)chlorophosphinyl]-, methyl ester
• CAS NO: 217090-42-1
• Molecular Formula: C10H12BrClNO4P
• Molecular Weight: 356.54
• Mol File: 217090-42-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(4-bromophenoxy)chlorophosphinyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(4-bromophenoxy)chlorophosphinyl]-, methyl ester(217090-42-1)
• EPA Substance Registry System: L-Alanine, N-[(4-bromophenoxy)chlorophosphinyl]-, methyl ester(217090-42-1)

Safety Data

• Hazardous Substances Data: 217090-42-1(Hazardous Substances Data)

Upstream product

• 10065-72-2 L-Alanine methyl ester 
• 19430-76-3 p-bromophenyl phosphorodichloridate 
• 106-41-2 4-bromo-phenol 
• 2491-20-5 L-alanine methyl ester hydrochloride 

Downstream Products

• 217178-62-6 Stampidine 
• 220693-38-9 3'-azidothymidine-5'-(p-bromophenyl)methoxyalaninyl phosphate 
• 217178-62-6 N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester 
• 213982-96-8 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate 
• 1064684-25-8 (S)-2-{(4-bromophenoxy)[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy]phosphorylamino}propionic acid methyl ester 

Relevant articles and documents

Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent

The arylphosphoramidate derivative of stavudine (STV, d4T, 2',3'-didehydro-3'-deoxythymidine, CAS 3056-17-5), stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6), is a n

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate. ECV · Editio Cantor Verlag, Aulendorf (Germany).

Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: Aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07)

aryl phosphate derivative of zidovudine (ZDV), is a potent dual-function contraceptive agent with anti-HIV activity. Its potential for reproductive toxicity was assessed in a series of experiments using CD-1 mice under the conditions of its intended use a