21718-94-5

Usage

Uses

Used in Pharmaceutical Research:
Ethanone, 1,1'-(2,4-quinolinediyl)bisis utilized as a key component in the development of antimalarial drugs due to its antiparasitic properties. It targets enzymes and proteins in the malaria parasite, offering a potential solution to combat the disease.
Used in Anti-inflammatory and Analgesic Applications:
In the medical field, Ethanone, 1,1'-(2,4-quinolinediyl)bisserves as an anti-inflammatory and analgesic agent. Its potential to alleviate inflammation and pain makes it a valuable compound for the treatment of various conditions that require these therapeutic effects.
Used in Drug Development:
Ethanone, 1,1'-(2,4-quinolinediyl)bisis employed in drug development for its multifaceted capabilities. Its interaction with biological targets and its demonstrated efficacy in various applications make it a versatile compound for creating new therapeutic agents.

Upstream product

• 91-22-5 quinoline 
• 513-86-0 3-hydroxy-2-butanon 
• 431-03-8 dimethylglyoxal 
• 111-34-2 -butyl vinyl ether 
• 122-51-0 orthoformic acid triethyl ester 

Relevant academic research and scientific papers

Metal-, Photocatalyst-, and Light-Free Minisci C-H Acetylation of N-Heteroarenes with Vinyl Ethers

Herein, we report a mild, operationally simple method for Minisci C-H acetylation of N-heteroarenes using vinyl ethers as robust, inexpensive acetyl sources. The reactions do not require a conventional photocatalysis, electrocatalysis, metal catalysis, light activation, or high temperature. This method is thus significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation. This protocol can be expected to obtain medically relevant molecules from abundant feedstock materials.

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Iron-Catalyzed Minisci Type Acetylation of N-Heteroarenes Mediated by CH(OEt)3/TBHP

Iron-catalyzed acetylation of electron deficient N-heteroarenes has been reported using triethylorthoformate as robust and inexpensive acetyl source. This new method is successfully applied for the acetylation of quinolines, isoquinoline, quinoxalines, arylpyridines, bipyridines, and benzothiazole.