217181-98-1

Upstream product

• 110840-39-6 (S)-(+)-2-(benzyloxy)-3-methylbutanal 

Downstream Products

• 228863-34-1 2-((1R,2S)-2-Benzyloxy-3-methyl-1-trimethylsilanyloxy-butyl)-malonic acid di-tert-butyl ester 
• 228863-35-2 2-((1S,2S)-2-Benzyloxy-3-methyl-1-trimethylsilanyloxy-butyl)-2-iodo-malonic acid di-tert-butyl ester 
• 228863-42-1 (2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide 
• 228863-36-3 (S)-3-((S)-1-Benzyloxy-2-methyl-propyl)-oxirane-2,2-dicarboxylic acid di-tert-butyl ester 
• 228863-43-2 (2R,3S)-3-((S)-1-Hydroxy-2-methyl-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide 

Relevant academic research and scientific papers

Synthetic study on L-755,807: Asymmetric synthesis of the epoxy-γ- lactam moiety

The optically active epoxy-γ-lactam moiety (-)-4 of the B2 selective bradykinin inhibitor L-755,807 1 was prepared from (S)-aldehyde 7 via an anti selective aldol reaction as the key step.