217182-06-4Relevant academic research and scientific papers
Oxazatricyclic noradamantanes: Stereocontrolled synthesis of functionalized scopolines, related cage molecules, and drug leads
Pascual, María Vidal,Proemmel, Steffen,Beil, Winfried,Wartchow, Rudolf,Hoffmann
, p. 4155 - 4158 (2004)
(Chemical Equation Presented) Scopolines 4 and the noradamantane scaffold are accessible from 8-oxabicyclo[3.2.1]oct-6-en-3-ones such as 6 by a concise route involving introduction of an axial amino nitrogen at C3, epoxidation, and cyclization. The result
Synthesis of dioxatricyclic segments of dictyoxetane. Oxygenated 6,8- dimethyl-2,7-dioxatricyclo[4.2.1.03,8]nonanes show antitumor activity
Wittenberg,Beil,Hoffmann
, p. 8259 - 8262 (1998)
Starting from 1,1-bisbenzyloxy propanone four oxetanes A, B, C and D representing the dioxatricyclic core of dictyoxetane were synthesized. All of them show a cytotoxic/cytostatic effect using a human gastric carcinoma and a human heptocellular cell line.
