2172-90-9

Upstream product

• 5326-34-1 4-Bromo-3-nitrotoluene 
• 100-67-4 potassium phenolate 
• 108-95-2 phenol 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 12775-96-1 copper 

Downstream Products

• 2172-91-0 5-Methyl-2-phenoxybenzenamine 
• 2914-76-3 (4-methyl-2-nitro-phenyl)-(4-nitro-phenyl)-ether 
• 60287-83-4 N-(5-methyl-2-phenoxy-phenyl)-formamide 
• 55113-22-9 8-methyl-dibenz[b,f][1,4]oxazepine 

Relevant academic research and scientific papers

An improved synthesis of dibenzofurans by a free-radical cyclization

Reaction conditions for the formation of dibenzofurans from diazotized o-(aryloxy)anilines have been examined. Several promoters (hydroquinone, SnCl2, NaI, CuSO4, FeSO4, etc.) have been discovered; these act as electron donors and promote a free-radical mechanism. The best of these is FeSO4 which shortens the reaction time from hours to minutes and contributes to high yields (77-83%). We have been able to transform the cyclization to a reliable and convenient synthesis.

1-,2-,3-,4-,5-,6-,7-,8- AND/OR 9 SUBSTITUTED DIBENZOXAZEPINE COMPOUDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING PAIN

The present invention provides substituted dibenzoxazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.