21722-66-7 Usage
General Description
1-(1,3-Benzodioxol-5-ylcarbonyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid is a complex chemical compound with a long and distinctive name. It contains a 1,3-benzodioxole ring, a carbonyl group, a methoxy group, a methyl group, and an indole ring. 1-(1,3-Benzodioxol-5-ylcarbonyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid has a carboxylic acid group, indicating that it is an acidic compound. It is also a derivative of the neurotransmitter serotonin and is structurally related to the psychedelic compound known as 5-MeO-MIPT. This chemical compound may have potential pharmaceutical or biochemical applications, and its complex structure suggests that it may have diverse biological effects.
Check Digit Verification of cas no
The CAS Registry Mumber 21722-66-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,2 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 21722-66:
(7*2)+(6*1)+(5*7)+(4*2)+(3*2)+(2*6)+(1*6)=87
87 % 10 = 7
So 21722-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H17NO6/c1-11-14(9-19(22)23)15-8-13(25-2)4-5-16(15)21(11)20(24)12-3-6-17-18(7-12)27-10-26-17/h3-8H,9-10H2,1-2H3,(H,22,23)
21722-66-7Relevant articles and documents
Chemical structure and anti-inflammatory activity in the group of substituted indole-3-acetic acids
Boltze,Brendler,Jacobi,Opitz,Raddatz,Seidel,Vollbrecht
, p. 1314 - 1325 (2007/10/02)
The chemical structure of the indometacin molecule was systematically modified with the aim of producing a substance with increased anti-inflammatory activity and improved tolerance. In addition to the variations of the methylene group of the indole-3-acetic acid and substituents on the indole nucleus of indometacin, particular attention was paid to the modification of the carboxyl group of the acetic acid side chain. Among the indometacin esters, one derivative, the [1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy] acetic acid (54), showed an activity approximately twice that of indometacin in the kaolin edema test in the rat paw. Chemical modification of the new compound 54 did not further improve the activity. These studies suggest that specific substitutions on the indole nucleus, in combination with the acetic acid side chain as in 1, and especially the acetoxy acetic acid side chain in 54 are responsible for the high anti-inflammatory activity of this class of substances. Several methods for the synthesis of acemetacin are described.
