21724-83-4

Usage

Uses

Used in Organic Synthesis:
2-Chloro-4-isothiocyanatobenzonitrile is used as a reagent in organic synthesis reactions for its ability to react with various functional groups, facilitating the formation of new chemical entities.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-chloro-4-isothiocyanatobenzonitrile is used as a precursor for the synthesis of active pharmaceutical ingredients, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
Similarly, in the agrochemical sector, 2-chloro-4-isothiocyanatobenzonitrile is utilized as a starting material for the synthesis of various agrochemicals, including pesticides and herbicides, aimed at enhancing crop protection and yield.
Safety Considerations:

Upstream product

• 463-71-8 thiophosgene 
• 20925-27-3 4-amino-2-chlorobenzonitrile 

Downstream Products

• 1257531-91-1 3-(3-chloro-4-cyanophenyl)-6-(R)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257531-87-5 3-(3-chloro-4-cyanophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257531-97-7 3-(3-chloro-4-cyanophenyl)-6-(R)-methyl-1-[(R)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257532-00-5 3-(3-chloro-4-cyanophenyl)-6-(S)-methyl-1-[(R)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1097799-55-7 4-[(3-chloro-4-cyano)phenyl]-3-thiosemicarbazide 
• 1616932-04-7 C₁₅H₁₃ClN₄S 
• 1214896-01-1 3-(3-chloro-4-cyanophenyl)-1-(1-phenylethyl)-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1214896-26-0 2-chloro-4-(3-ethyl-6-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)benzonitrile 
• 1214896-13-5 4-(3-benzyl-6-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-chlorobenzonitrile 

Relevant academic research and scientific papers

SUBSTITUTED 3-((3-AMINOPHENYL)AMINO)PIPERIDINE-2,6-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are piperidine dione compounds having the following structure (I) wherein RN, R1, R2, R3, R4, L,V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR

The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR

The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.

IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE

New imidazoline derivatives represented by formula (I), preparation methods thereof, pharmaceutical compositions comprising such derivatives, and applications of such derivatives in preparing androgen receptor antagonists and medicaments for treating diseases such as prostate cancer.

IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE

New imidazoline derivatives represented by formula (I): preparation methods thereof, pharmaceutical compositions comprising such derivatives, and applications of such derivatives in preparing androgen receptor antagonists and medicaments for treating diseases such as prostate cancer are described.

NON-STEROIDAL ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS WITH A PYRIDYL MOIETY

Compounds having the structure or their salts: are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia, male baldness, muscle atrophy and weakness, sarcopenia, male hypogonadism, erectile dysfunction, female sexual dysfunction and osteoporosis. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

TRIAZOLE COMPOUNDS AS ANTIVIRALS

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.