21724-83-4

Basic information

• Product Name: 2-chloro-4-isothiocyanatobenzonitrile
• Synonyms: 2-chloro-4-isothiocyanatobenzonitrile;3-chloro-4-isothiocyanatobenzonitrile
• CAS NO: 21724-83-4
• Molecular Formula: C₈H₃ClN₂S
• Molecular Weight: 194.64082
• Mol File: 21724-83-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 77.5 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 367.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-chloro-4-isothiocyanatobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-isothiocyanatobenzonitrile(21724-83-4)
• EPA Substance Registry System: 2-chloro-4-isothiocyanatobenzonitrile(21724-83-4)

Safety Data

• Hazardous Substances Data: 21724-83-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-isothiocyanatobenzonitrile is a chemical compound with the molecular formula C8H3ClN2S. It is an isothiocyanate derivative of benzonitrile, which is commonly used as a precursor for the synthesis of other organic compounds. 2-Chloro-4-isothiocyanatobenzonitrile is known for its strong, pungent odor and is often used as a reagent in organic synthesis reactions. It is also utilized in the development of pharmaceuticals and agrochemicals. Additionally, it is considered to be a potential irritant to the skin, eyes, and respiratory system, and caution should be taken when handling this chemical compound.

Upstream product

• 463-71-8 thiophosgene 
• 20925-27-3 4-amino-2-chlorobenzonitrile 

Downstream Products

• 875056-37-4 C₂₀H₂₆ClN₅O₃S₂ 
• 875056-29-4 C₂₁H₂₇ClN₄O₅S₂ 
• 875056-28-3 N-(1-dimethylaminomethylidene)-3-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide 
• 875056-33-0 C₁₉H₂₄ClN₅O₃S₂ 
• 1214896-13-5 4-(3-benzyl-6-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)-2-chlorobenzonitrile 
• 1214896-26-0 2-chloro-4-(3-ethyl-6-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)benzonitrile 
• 1214896-01-1 3-(3-chloro-4-cyanophenyl)-1-(1-phenylethyl)-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257531-91-1 3-(3-chloro-4-cyanophenyl)-6-(R)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257531-87-5 3-(3-chloro-4-cyanophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257531-97-7 3-(3-chloro-4-cyanophenyl)-6-(R)-methyl-1-[(R)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1257532-00-5 3-(3-chloro-4-cyanophenyl)-6-(S)-methyl-1-[(R)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one 
• 1259327-72-4 6-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid dibenzylamide 
• 1259327-73-5 5-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid dibenzylamide 
• 875056-38-5 2-chloro-4-(4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)benzonitrile 

Relevant articles and documents

CRYSTAL OF DIARYLTHIOHYDANTOIN COMPOUND

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DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.

MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.