875056-38-5Relevant academic research and scientific papers
Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer
Yoshino, Hitoshi,Sato, Haruhiko,Shiraishi, Takuya,Tachibana, Kazutaka,Emura, Takashi,Honma, Akie,Ishikura, Nobuyuki,Tsunenari, Toshiaki,Watanabe, Miho,Nishimoto, Ayako,Nakamura, Ryo,Nakagawa, Toshito,Ohta, Masateru,Takata, Noriyuki,Furumoto, Kentaro,Kimura, Kazuya,Kawata, Hiromitsu
experimental part, p. 8150 - 8157 (2011/02/22)
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of castration-resistant prostate cancer. Since CH4933468, which we reported previously, had a problem wit
NOVEL IMIDAZOLIDINE DERIVATIVES
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Page/Page column 66, (2010/10/19)
Compounds represented by the general formula (I); and drugs and medicinal compositions, containing the compounds: (I) wherein n is an integer of 1 to 20; Q is (II) or (III) A is cyano or the like; B is hydrogen, halogeno, or the like; X1 and X
